A minimally invasive treatment for lumbar disc herniation: DiscoGel® chemonucleolysis in patients unresponsive to chemonucleolysis with oxygen-ozone

S. Stagni, F. De Santis, L. Cirillo, M. Dall'Olio, C. Princiotta, L. Simonetti, A. Stafa, Marco Leonardi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A multitude of therapies is available to treat disc herniation, ranging from conservative methods (medication and physical therapy) to minimally invasive (percutaneous) treatments and surgery. O 2-O 3 chemonucleolysis (O 2-O 3 therapy) is one of the minimally invasive treatments with the best cost/benefit ratio and lowest complication rate. Another substance recently made available exploiting the chemical properties of pure ethanol is DiscoGel®, a radiopaque gelified ethanol more viscous than absolute alcohol 8,9. The present study aimed to assess the therapeutic outcome of DiscoGel® chemonucleolysis in patients with lumbar disc herniation unresponsive to O 2-O 3 therapy. Thirty-two patients aged between 20 and 79 years were treated by DiscoGel® chemonucleolysis between December 2008 and January 2010. The treatment was successful (improvement in pain) in 24 out of 32 patients. DiscoGel® is safe and easy to handle and there were no complications related to product diffusivity outside the treatment site. The therapeutic success rate of DiscoGel® chemonucleolysis in patients unresponsive to O 2-O 3 therapy was satisfactory. Among other methods used to treat lumbar disc herniation, DiscoGel® chemonucleolysis can be deemed an intermediate procedure bridging conservative medical treatments and surgery.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalInterventional Neuroradiology
Volume18
Issue number1
Publication statusPublished - Mar 2012

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Intervertebral Disc Chemolysis
Ozone
Oxygen
Therapeutics
Ethanol
Cost-Benefit Analysis

Keywords

  • Discal hernia
  • DiscoGel
  • Ozone
  • Percutaneous treatments

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "A multitude of therapies is available to treat disc herniation, ranging from conservative methods (medication and physical therapy) to minimally invasive (percutaneous) treatments and surgery. O 2-O 3 chemonucleolysis (O 2-O 3 therapy) is one of the minimally invasive treatments with the best cost/benefit ratio and lowest complication rate. Another substance recently made available exploiting the chemical properties of pure ethanol is DiscoGel{\circledR}, a radiopaque gelified ethanol more viscous than absolute alcohol 8,9. The present study aimed to assess the therapeutic outcome of DiscoGel{\circledR} chemonucleolysis in patients with lumbar disc herniation unresponsive to O 2-O 3 therapy. Thirty-two patients aged between 20 and 79 years were treated by DiscoGel{\circledR} chemonucleolysis between December 2008 and January 2010. The treatment was successful (improvement in pain) in 24 out of 32 patients. DiscoGel{\circledR} is safe and easy to handle and there were no complications related to product diffusivity outside the treatment site. The therapeutic success rate of DiscoGel{\circledR} chemonucleolysis in patients unresponsive to O 2-O 3 therapy was satisfactory. Among other methods used to treat lumbar disc herniation, DiscoGel{\circledR} chemonucleolysis can be deemed an intermediate procedure bridging conservative medical treatments and surgery.",
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AU - De Santis, F.

AU - Cirillo, L.

AU - Dall'Olio, M.

AU - Princiotta, C.

AU - Simonetti, L.

AU - Stafa, A.

AU - Leonardi, Marco

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