Proposta di un modello e di una tassonomia utili per valutare il valore (caratteristiche, attivita ed efficacia) delle linee-guida

Translated title of the contribution: A model for an evaluation of clinical guide-lines

G. Apolone, F. Bamfi

Research output: Contribution to journalArticlepeer-review


Clinical practice guidelines are systematically developed statements that assist in decision-making about appropriate care for specific clinical decisions. Most of them were developed in the past according to old techniques, while the most recent ones have been developed on the basis of the principles of evidence-based medical care. In contrast with the large amount of guidelines available for almost all the relevant medical conditions, very few data exist about their effectiveness, namely about their capability to improve patients' health outcomes. Most of the empirical evidence available is infact limited to their intrinsic characteristics and, at the best, to their impact on the process of care. The lack of outcome data is usually attributed by experts to the lack of interested sponsors, as well as to the methodological difficulty of taking into account all factors and barriers that might confound the effect of guidelines. Using as an example the different phases of drug development, we propose that the use of a similar approach might help better structure the process of development and validation of clinical practice guidelines.

Translated title of the contributionA model for an evaluation of clinical guide-lines
Original languageItalian
Pages (from-to)116-124
Number of pages9
JournalRicerca e Pratica
Issue number87
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Pharmacology


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