A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

Sara Piccinonna, Nicola Margiotta, Nunzio Denora, Rosa Maria Iacobazzi, Concetta Pacifico, Giuseppe Trapani, Giovanni Natile

Research output: Contribution to journalArticlepeer-review

Abstract

A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

Original languageEnglish
Pages (from-to)10112-10115
Number of pages4
JournalDalton Transactions
Volume42
Issue number28
DOIs
Publication statusPublished - Jul 28 2013

ASJC Scopus subject areas

  • Inorganic Chemistry

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