A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

Sara Piccinonna; Nicola Margiotta; Nunzio Denora; Rosa Maria Iacobazzi; Concetta Pacifico; Giuseppe Trapani; Giovanni Natile

doi:10.1039/c3dt51152a

A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

Sara Piccinonna, Nicola Margiotta, Nunzio Denora, Rosa Maria Iacobazzi, Concetta Pacifico, Giuseppe Trapani, Giovanni Natile

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new ^99mTc or ^188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)₃(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

Original language	English
Pages (from-to)	10112-10115
Number of pages	4
Journal	Dalton Transactions
Volume	42
Issue number	28
DOIs	https://doi.org/10.1039/c3dt51152a
Publication status	Published - Jul 28 2013

ASJC Scopus subject areas

Inorganic Chemistry

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10.1039/c3dt51152a

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AU - Piccinonna, Sara

AU - Margiotta, Nicola

AU - Denora, Nunzio

AU - Iacobazzi, Rosa Maria

AU - Pacifico, Concetta

AU - Trapani, Giuseppe

AU - Natile, Giovanni

PY - 2013/7/28

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AB - A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

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