A modified cell block technique for fine needle aspiration cytology

F. A. Zito, C. D. Gadaleta, C. Salvatore, R. Filotico, A. Labriola, A. Marzullo, F. Prete, F. Marzullo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A modification of the cell block technique, useful in processing material obtained by fine needle aspiration (FNA), is described. Four hundred six aspirates, obtained from 333 consecutive patients, were studied after immediate fixation in 4% buffered paraformaldehyde. Conventional histochemical and immunohistochemical staining methods were used. Histologic verification of the cytologic diagnoses made by FNA was possible in 67 cases. The overall accuracy was 97%, with a sensitivity of 95% and specificity of 100%. A major disadvantage of the cell block technique is time. Therefore, even if this technique increases the accuracy of cytologic diagnosis, its routine use is impractical because the delay in diagnosis when compared with smears may be considerable. The cell block technique is a valuable method, particularly when immunohistochemical staining for a battery of markers is required.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalActa Cytologica
Volume39
Issue number1
Publication statusPublished - 1995

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Fine Needle Biopsy
Cell Biology
Staining and Labeling
Sensitivity and Specificity

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Zito, F. A., Gadaleta, C. D., Salvatore, C., Filotico, R., Labriola, A., Marzullo, A., ... Marzullo, F. (1995). A modified cell block technique for fine needle aspiration cytology. Acta Cytologica, 39(1), 93-99.

A modified cell block technique for fine needle aspiration cytology. / Zito, F. A.; Gadaleta, C. D.; Salvatore, C.; Filotico, R.; Labriola, A.; Marzullo, A.; Prete, F.; Marzullo, F.

In: Acta Cytologica, Vol. 39, No. 1, 1995, p. 93-99.

Research output: Contribution to journalArticle

Zito, FA, Gadaleta, CD, Salvatore, C, Filotico, R, Labriola, A, Marzullo, A, Prete, F & Marzullo, F 1995, 'A modified cell block technique for fine needle aspiration cytology', Acta Cytologica, vol. 39, no. 1, pp. 93-99.
Zito FA, Gadaleta CD, Salvatore C, Filotico R, Labriola A, Marzullo A et al. A modified cell block technique for fine needle aspiration cytology. Acta Cytologica. 1995;39(1):93-99.
Zito, F. A. ; Gadaleta, C. D. ; Salvatore, C. ; Filotico, R. ; Labriola, A. ; Marzullo, A. ; Prete, F. ; Marzullo, F. / A modified cell block technique for fine needle aspiration cytology. In: Acta Cytologica. 1995 ; Vol. 39, No. 1. pp. 93-99.
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