A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution

Flavio Dell'Acqua, Paola Scifo, Giovanna Rizzo, Marco Catani, Andrew Simmons, Giuseppe Scotti, Ferruccio Fazio

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Spherical deconvolution methods have been applied to diffusion MRI to improve diffusion tensor tractography results in brain regions with multiple fibre crossing. Recent developments, such as the introduction of non-negative constraints on the solution, allow a more accurate estimation of fibre orientations by reducing instability effects due to noise robustness. Standard convolution methods do not, however, adequately model the effects of partial volume from isotropic tissue, such as gray matter, or cerebrospinal fluid, which may degrade spherical deconvolution results. Here we use a newly developed spherical deconvolution algorithm based on an adaptive regularization (damped version of the Richardson-Lucy algorithm) to reduce isotropic partial volume effects. Results from both simulated and in vivo datasets show that, compared to a standard non-negative constrained algorithm, the damped Richardson-Lucy algorithm reduces spurious fibre orientations and preserves angular resolution of the main fibre orientations. These findings suggest that, in some brain regions, non-negative constraints alone may not be sufficient to reduce spurious fibre orientations. Considering both the speed of processing and the scan time required, this new method has the potential for better characterizing white matter anatomy and the integrity of pathological tissue.

Original languageEnglish
Pages (from-to)1446-1458
Number of pages13
JournalNeuroImage
Volume49
Issue number2
DOIs
Publication statusPublished - Jan 15 2010

Fingerprint

Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Brain
Cerebrospinal Fluid
Noise
Anatomy
White Matter
Gray Matter
Datasets

Keywords

  • Diffusion MRI
  • Fibre crossing
  • Isotropic partial volume
  • Richardson Lucy algorithm
  • Spherical deconvolution

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Dell'Acqua, F., Scifo, P., Rizzo, G., Catani, M., Simmons, A., Scotti, G., & Fazio, F. (2010). A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution. NeuroImage, 49(2), 1446-1458. https://doi.org/10.1016/j.neuroimage.2009.09.033

A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution. / Dell'Acqua, Flavio; Scifo, Paola; Rizzo, Giovanna; Catani, Marco; Simmons, Andrew; Scotti, Giuseppe; Fazio, Ferruccio.

In: NeuroImage, Vol. 49, No. 2, 15.01.2010, p. 1446-1458.

Research output: Contribution to journalArticle

Dell'Acqua, F, Scifo, P, Rizzo, G, Catani, M, Simmons, A, Scotti, G & Fazio, F 2010, 'A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution', NeuroImage, vol. 49, no. 2, pp. 1446-1458. https://doi.org/10.1016/j.neuroimage.2009.09.033
Dell'Acqua, Flavio ; Scifo, Paola ; Rizzo, Giovanna ; Catani, Marco ; Simmons, Andrew ; Scotti, Giuseppe ; Fazio, Ferruccio. / A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution. In: NeuroImage. 2010 ; Vol. 49, No. 2. pp. 1446-1458.
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