A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis

Giovanni Palladini, Ernesto Anesi, Vittorio Perfetti, Laura Obici, Rosangela Invernizzi, Carlo Balduini, Edoardo Ascari, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review

Abstract

High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d 1-4 q21 d for up to eight cycles. Overall 8 out of 23 (35%) treated patients responded to treatment in a median time of 4 months (range 2-6 months) without significant toxicity. This regimen may be considered front-line therapy when autologous stem cell transplantation is not feasible and when a rapid response is particularly important.

Original languageEnglish
Pages (from-to)1044-1046
Number of pages3
JournalBritish Journal of Haematology
Volume113
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • AL amyloidosis
  • High-dose dexamethasone
  • Response time
  • Survival

ASJC Scopus subject areas

  • Hematology

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