A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis

Giovanni Palladini; Ernesto Anesi; Vittorio Perfetti; Laura Obici; Rosangela Invernizzi; Carlo Balduini; Edoardo Ascari; Giampaolo Merlini

doi:10.1046/j.1365-2141.2001.02859.x

A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis

Giovanni Palladini, Ernesto Anesi, Vittorio Perfetti, Laura Obici, Rosangela Invernizzi, Carlo Balduini, Edoardo Ascari, Giampaolo Merlini

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d 1-4 q21 d for up to eight cycles. Overall 8 out of 23 (35%) treated patients responded to treatment in a median time of 4 months (range 2-6 months) without significant toxicity. This regimen may be considered front-line therapy when autologous stem cell transplantation is not feasible and when a rapid response is particularly important.

Original language	English
Pages (from-to)	1044-1046
Number of pages	3
Journal	British Journal of Haematology
Volume	113
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02859.x
Publication status	Published - 2001

Keywords

AL amyloidosis
High-dose dexamethasone
Response time
Survival

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2001.02859.x

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A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis. / Palladini, Giovanni; Anesi, Ernesto; Perfetti, Vittorio; Obici, Laura ; Invernizzi, Rosangela; Balduini, Carlo; Ascari, Edoardo; Merlini, Giampaolo.

In: British Journal of Haematology, Vol. 113, No. 4, 2001, p. 1044-1046.

Research output: Contribution to journal › Article › peer-review

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AU - Palladini, Giovanni

AU - Anesi, Ernesto

AU - Perfetti, Vittorio

AU - Obici, Laura

AU - Invernizzi, Rosangela

AU - Balduini, Carlo

AU - Ascari, Edoardo

AU - Merlini, Giampaolo

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AB - High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d 1-4 q21 d for up to eight cycles. Overall 8 out of 23 (35%) treated patients responded to treatment in a median time of 4 months (range 2-6 months) without significant toxicity. This regimen may be considered front-line therapy when autologous stem cell transplantation is not feasible and when a rapid response is particularly important.

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KW - Response time

KW - Survival

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A modified high-dose dexamethasone regimen for primary systemic (AL) amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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