Abstract
High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d 1-4 q21 d for up to eight cycles. Overall 8 out of 23 (35%) treated patients responded to treatment in a median time of 4 months (range 2-6 months) without significant toxicity. This regimen may be considered front-line therapy when autologous stem cell transplantation is not feasible and when a rapid response is particularly important.
Original language | English |
---|---|
Pages (from-to) | 1044-1046 |
Number of pages | 3 |
Journal | British Journal of Haematology |
Volume | 113 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- AL amyloidosis
- High-dose dexamethasone
- Response time
- Survival
ASJC Scopus subject areas
- Hematology