A Modified One-Stage Early Correction of Blepharophimosis Syndrome Using Tutopatch Slings

Gustavo Savino, Erika Mandarà, Luigi Calandriello, Anna Dickmann, Sergio Petroni

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate the efficacy of a one-stage early correction of blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), using bovine pericardium derived membrane (TUTOPATCH®) for the frontalis suspension. Methods: We prospectively studied 12 eyes from 6 patients (median age 14 months) affected by BPES with severe ptosis. All patients were submitted to a one-stage early correction of ptosis (frontalis suspension with TUTOPACH®) and telecanthus and epicanthus inversus. Upper margin reflex distance (MRD), nasal inner intercanthal distance (IICD), horizontal fissure length (HFL), and IICD/HFL ratio were evaluated using photographs. Results: The Wilcoxon signed-rank test showed a statistically significant difference between pre- and post-operative MRD, IICD, HFL, and the IICD/HFL ratio. Conclusion: An early TUTOPATCH-assisted frontalis suspension, together with the correction of telecanthus and epicanthus inversus, is an effective procedure for BPES cases with severe ptosis.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
Issue number4
Publication statusPublished - Aug 1 2015


  • Blepharophimosis-ptosis-epicanthus inversus syndrome
  • bovine pericardium derived membrane (TUTOPATCH®)
  • eyelid frontalis suspension

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'A Modified One-Stage Early Correction of Blepharophimosis Syndrome Using Tutopatch Slings'. Together they form a unique fingerprint.

Cite this