TY - JOUR
T1 - A modified physiologic test for bronchopulmonary dysplasia
T2 - A clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?
AU - Vento, Giovanni
AU - Vendettuoli, Valentina
AU - Aurilia, Claudia
AU - Tana, Milena
AU - Tirone, Chiara
AU - Lio, Alessandra
AU - Matassa, Piero Giuseppe
AU - Priolo, Francesca
AU - Catenazzi, Piero
AU - Corsello, Mirta
AU - Zecca, Enrico
AU - Mosca, Fabio
PY - 2019/1/4
Y1 - 2019/1/4
N2 -
Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Methods: Neonates with BW 500-1250 g and GA ≤ 32 weeks, receiving FiO
2
≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO
2
and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO
2
was added to SpO
2
and the newborns passing the test were left in room air. Results: Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO
2
were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO
2
were significantly higher in the latter babies. Conclusion: TcPCO
2
monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.
AB -
Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Methods: Neonates with BW 500-1250 g and GA ≤ 32 weeks, receiving FiO
2
≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO
2
and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO
2
was added to SpO
2
and the newborns passing the test were left in room air. Results: Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO
2
were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO
2
were significantly higher in the latter babies. Conclusion: TcPCO
2
monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.
KW - Physiologic test
KW - Preterm infants
KW - Respiratory support weaning
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U2 - 10.1186/s13052-018-0582-x
DO - 10.1186/s13052-018-0582-x
M3 - Article
C2 - 30609929
AN - SCOPUS:85059497286
VL - 45
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
SN - 1720-8424
IS - 1
M1 - 2
ER -