Abstract
Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Methods: Neonates with BW 500-1250 g and GA ≤ 32 weeks, receiving FiO 2 ≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO 2 and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO 2 was added to SpO 2 and the newborns passing the test were left in room air. Results: Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO 2 were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO 2 were significantly higher in the latter babies. Conclusion: TcPCO 2 monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.
| Original language | English |
|---|---|
| Article number | 2 |
| Journal | Italian Journal of Pediatrics |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 4 2019 |
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Keywords
- Physiologic test
- Preterm infants
- Respiratory support weaning
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
A modified physiologic test for bronchopulmonary dysplasia : A clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies? / Vento, Giovanni; Vendettuoli, Valentina; Aurilia, Claudia; Tana, Milena; Tirone, Chiara; Lio, Alessandra; Matassa, Piero Giuseppe; Priolo, Francesca; Catenazzi, Piero; Corsello, Mirta; Zecca, Enrico; Mosca, Fabio.
In: Italian Journal of Pediatrics, Vol. 45, No. 1, 2, 04.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A modified physiologic test for bronchopulmonary dysplasia
T2 - A clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?
AU - Vento, Giovanni
AU - Vendettuoli, Valentina
AU - Aurilia, Claudia
AU - Tana, Milena
AU - Tirone, Chiara
AU - Lio, Alessandra
AU - Matassa, Piero Giuseppe
AU - Priolo, Francesca
AU - Catenazzi, Piero
AU - Corsello, Mirta
AU - Zecca, Enrico
AU - Mosca, Fabio
PY - 2019/1/4
Y1 - 2019/1/4
N2 - Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Methods: Neonates with BW 500-1250 g and GA ≤ 32 weeks, receiving FiO 2 ≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO 2 and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO 2 was added to SpO 2 and the newborns passing the test were left in room air. Results: Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO 2 were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO 2 were significantly higher in the latter babies. Conclusion: TcPCO 2 monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.
AB - Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Methods: Neonates with BW 500-1250 g and GA ≤ 32 weeks, receiving FiO 2 ≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO 2 and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO 2 was added to SpO 2 and the newborns passing the test were left in room air. Results: Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO 2 were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO 2 were significantly higher in the latter babies. Conclusion: TcPCO 2 monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.
KW - Physiologic test
KW - Preterm infants
KW - Respiratory support weaning
UR - http://www.scopus.com/inward/record.url?scp=85059497286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059497286&partnerID=8YFLogxK
U2 - 10.1186/s13052-018-0582-x
DO - 10.1186/s13052-018-0582-x
M3 - Article
C2 - 30609929
AN - SCOPUS:85059497286
VL - 45
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
SN - 1720-8424
IS - 1
M1 - 2
ER -