A Modified Post-Transplant Cyclophosphamide Regimen, for Unmanipulated Haploidentical Marrow Transplantation, in Acute Myeloid Leukemia: A Multicenter Study

P. Chiusolo, G. Bug, A. Olivieri, M. Brune, N. Mordini, P.E. Alessandrino, A. Dominietto, A.M. Raiola, C. Di Grazia, F. Gualandi, M.T. Van Lint, F. Ferrara, O. Finizio, E. Angelucci, A. Bacigalupo

Research output: Contribution to journalArticlepeer-review

Abstract

We report a modified post-transplant cyclophosphamide (PT-CY) regimen, for unmanipulated haploidentical marrow transplants, in 150 patients with acute myeloid leukemia (AML). All patients received a myeloablative regimen, cyclosporine A (CsA) on day 0, mycophenolate on day +1, and PT-CY 50 mg/kg on days +3 and +5. The median age was 51 (range, 17–74) years, 51 (34%) patients had active disease at transplant, and the median follow-up of surviving patients 903 (range, 150-1955) days. The cumulative incidence (CI) of engraftment, acute graft-versus-host disease (GVHD) grade II to IV, and moderate/severe chronic GVHD was 92%, 17%, and 15%, respectively. The 4-year CI of transplant-related mortality (TRM) and relapse was 20% and 24%, respectively. Four-year survival for remission patients was 72% (74% versus 67% for
Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number6
DOIs
Publication statusPublished - 2018

Keywords

  • busulfan
  • cyclophosphamide
  • cyclosporine
  • fludarabine
  • mycophenolic acid
  • thiotepa, acute graft versus host disease
  • acute myeloid leukemia
  • adolescent
  • adult
  • aged
  • Article
  • bone marrow transplantation
  • cancer survival
  • chronic graft versus host disease
  • disease free survival
  • disease severity
  • engraftment
  • female
  • follow up
  • haploidentical transplantation
  • human
  • incidence
  • leukemia relapse
  • leukemia remission
  • major clinical study
  • male
  • mortality
  • myeloablative conditioning
  • overall survival
  • retrospective study

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