A modified rosette inhibition test in renal allotransplantation

Alberto Cantaluppi, Claudio Ponticelli, Francesco Salerno, Gemino Fiorelli

Research output: Contribution to journalArticlepeer-review


The rosette inhibition test, with a modification of the technique which enables highly accurate marking of T lymphocytes, has been employed in the followup of 55 renal transplant patients. The minimal inhibitory concentration of antilymphocyte globulin (that is, that concentration of antilymphoeyte globulin causing 25% inhibition of rosette'formation) was higher than 1:16,000 in 63 (97%) of 65 separate determina¬tions made during acute rejection episodes, and lower than 1:16,000 in 377 (92%) of 410 determinations after which no clinical evidence of rejection developed. The results presented in this paper indicate that this modified test is a useful tool either to predict the occurrence of or to confirm the diagnosis of rejection.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
Issue number2
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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