A modified rosette inhibition test in the early diagnosis of renal allograft rejection.

A. Cantaluppi, C. Ponticelli, G. Fiorelli

Research output: Contribution to journalArticle

Abstract

The rosette inhibition test has been employed in the follow-up of 30 renal transplant patients using a technique which enables highly accurate marking of T-lymphocytes. The minimal inhibitory concentration (MIC) of anti-lymphocyte globulin (ALG) - that is, that concentration of ALG causing 25% inhibition of rosette formation-was higher than 1/16,000 in 32 (97%) out of 33 separate determinations made two to six days befor rejection became clinically evident, and lower than 1/16,000 in 323 (92%) out of 351 determinations after which no clinical evidence of rejection developed. The results presented in this paper indicate that this modified test is a useful tool either to predict the occurrence of or to confirm the diagnosis of rejection.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalProceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
Volume11
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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