A molecular investigation suggests no relationship between obsessive-compulsive disorder and the dopamine D2 receptor

Emanuela Novelli, Maria Nobile, Giuseppina Diaferia, Gabriella Sciuto, Marco Catalano

Research output: Contribution to journalArticle

Abstract

Some studies suggest a relationship between obsessive-compulsive disorder (OCD) and Gilles de la Tourette’s syndrome. The pathophysiology of the latter may involve the dopamine system. We screened three important exons of the dopamine D2 receptor (DRD2) gene for mutations in a group of OCD patients with or without tics. No structural changes were found, suggesting no relation-ship between DRD2 and OCD. Moreover, the frequency of the polymorphism in exon 6 was different from that found in schizophrenics.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalNeuropsychobiology
Volume29
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • Denaturing gradient gel electrophoresis
  • DNA
  • Dopamine D<inf>2</inf> receptor gene
  • Obsessive-compulsive disorder tics
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

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