A monoclonal antibody to CD11c antigen inhibits the production of superoxide anion induced by concanavalin A in PMA-differentiated U-937 cells

Carlos Cabañas, Pedro Lacal, Faustino Mollinedo, Abelardo López-Rivas, Francisco Sánchez-Madrid, Carmelo Bernabeu

Research output: Contribution to journalArticle

Abstract

We have examined the effect of different monoclonal antibodies (MAb) to the CD11/CD18 family of surface antigens on the production of superoxide anion by phorbol myristate acetate (PMA)-differentiated U-937 cells upon stimulation with concanavalin A (Con A). The anti-CD11c MAb HC1/1 displayed a significant inhibition, whereas MAb to the other members of the CD11 family did not show a relevant inhibitory effect. These findings suggest that the CD11c antigen is involved in the triggering of the respiratory burst response by mononuclear phagocytic cells.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalImmunology Letters
Volume20
Issue number3
DOIs
Publication statusPublished - 1989

Keywords

  • CD11c antigen
  • Superoxide anion
  • U-937 cell line

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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