A more in-depth interpretation of MMPI-2 in MS patients by using Harris and Lingoes subscales

Chiara C. Incerti, Ornella Argento, Valerio Pisani, Giuseppe Magistrale, Ugo Sabatello, Carlo Caltagirone, Ugo Nocentini

Research output: Contribution to journalArticlepeer-review


Multiple Sclerosis (MS) is frequently associated with neuropsychiatric abnormalities. The aim of our study was to discriminate between psychosomatic disturbances and MS physically-related symptoms using the Harris-Lingoes subscales of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Forty-six MS out-patients (35 females; mean age = 44.5); and 82 healthy volunteers (62 females; mean age = 46.5) were evaluated with MMPI-2 questionnaire. The frequency distribution of MMPI-2 clinical scales with high scores (> = 65) and the related Harris-Lingoes subscales were analyzed for both MS patients and healthy control subjects. Data analysis showed elevated scores in 47.8% of the patients mainly on MMPI-2 clinical scales 1, 2, and 3. The Harris-Lingoes subscales analysis allowed us to isolate and identify physical symptoms contributing to elevation of MMPI-2 clinical scales, reduce the occurrence of false positives (MMPI-2 clinical scales elevations mainly due to MS physical disability) and provide a more detailed description of psycho-emotional symptoms of MS patients. In conclusion, our study shows the utility of Harris-Lingoes subscales analysis when MMPI-2 is used for psychological assessment of MS patients.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalApplied Neuropsychology:Adult
Publication statusAccepted/In press - Jun 29 2016


  • Depression
  • Minnesota Multiphasic Personality Inventory-2
  • multiple sclerosis
  • psychological evaluation

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology


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