A mouse model for valproate teratogenicity

Parental effects, homeotic transformations, and altered HOX expression

Antonio Faiella, Marius Wernig, G. Giacomo Consalez, Ute Hostick, Clementine Hofmann, Elisabeth Hustert, Edoardo Boncinelli, Rudi Balling, Joseph H. Nadeau

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors influence fetal susceptibility to induced malformations. Detailed examination of these malformations revealed that many were homeotic transformations. To test whether VPA, like retinoic acid (RA), alters HOX expression, pluripotent human embryonal carcinoma cells were treated with VPA or RA and Hox expression assessed. Altered expression of specific Hox genes may thus account for the homeotic transformations and other malformations found in VPA-treated fetuses.

Original languageEnglish
Pages (from-to)227-236
Number of pages10
JournalHuman Molecular Genetics
Volume9
Issue number2
Publication statusPublished - 2000

Fingerprint

Valproic Acid
Tretinoin
Teratogens
Embryonal Carcinoma Stem Cells
Inbred Strains Mice
Homeobox Genes
Fetus
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Genetics

Cite this

Faiella, A., Wernig, M., Consalez, G. G., Hostick, U., Hofmann, C., Hustert, E., ... Nadeau, J. H. (2000). A mouse model for valproate teratogenicity: Parental effects, homeotic transformations, and altered HOX expression. Human Molecular Genetics, 9(2), 227-236.

A mouse model for valproate teratogenicity : Parental effects, homeotic transformations, and altered HOX expression. / Faiella, Antonio; Wernig, Marius; Consalez, G. Giacomo; Hostick, Ute; Hofmann, Clementine; Hustert, Elisabeth; Boncinelli, Edoardo; Balling, Rudi; Nadeau, Joseph H.

In: Human Molecular Genetics, Vol. 9, No. 2, 2000, p. 227-236.

Research output: Contribution to journalArticle

Faiella, A, Wernig, M, Consalez, GG, Hostick, U, Hofmann, C, Hustert, E, Boncinelli, E, Balling, R & Nadeau, JH 2000, 'A mouse model for valproate teratogenicity: Parental effects, homeotic transformations, and altered HOX expression', Human Molecular Genetics, vol. 9, no. 2, pp. 227-236.
Faiella, Antonio ; Wernig, Marius ; Consalez, G. Giacomo ; Hostick, Ute ; Hofmann, Clementine ; Hustert, Elisabeth ; Boncinelli, Edoardo ; Balling, Rudi ; Nadeau, Joseph H. / A mouse model for valproate teratogenicity : Parental effects, homeotic transformations, and altered HOX expression. In: Human Molecular Genetics. 2000 ; Vol. 9, No. 2. pp. 227-236.
@article{dfe685170fcd4f57af9cd8bf3e8efc73,
title = "A mouse model for valproate teratogenicity: Parental effects, homeotic transformations, and altered HOX expression",
abstract = "Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors influence fetal susceptibility to induced malformations. Detailed examination of these malformations revealed that many were homeotic transformations. To test whether VPA, like retinoic acid (RA), alters HOX expression, pluripotent human embryonal carcinoma cells were treated with VPA or RA and Hox expression assessed. Altered expression of specific Hox genes may thus account for the homeotic transformations and other malformations found in VPA-treated fetuses.",
author = "Antonio Faiella and Marius Wernig and Consalez, {G. Giacomo} and Ute Hostick and Clementine Hofmann and Elisabeth Hustert and Edoardo Boncinelli and Rudi Balling and Nadeau, {Joseph H.}",
year = "2000",
language = "English",
volume = "9",
pages = "227--236",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - A mouse model for valproate teratogenicity

T2 - Parental effects, homeotic transformations, and altered HOX expression

AU - Faiella, Antonio

AU - Wernig, Marius

AU - Consalez, G. Giacomo

AU - Hostick, Ute

AU - Hofmann, Clementine

AU - Hustert, Elisabeth

AU - Boncinelli, Edoardo

AU - Balling, Rudi

AU - Nadeau, Joseph H.

PY - 2000

Y1 - 2000

N2 - Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors influence fetal susceptibility to induced malformations. Detailed examination of these malformations revealed that many were homeotic transformations. To test whether VPA, like retinoic acid (RA), alters HOX expression, pluripotent human embryonal carcinoma cells were treated with VPA or RA and Hox expression assessed. Altered expression of specific Hox genes may thus account for the homeotic transformations and other malformations found in VPA-treated fetuses.

AB - Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors influence fetal susceptibility to induced malformations. Detailed examination of these malformations revealed that many were homeotic transformations. To test whether VPA, like retinoic acid (RA), alters HOX expression, pluripotent human embryonal carcinoma cells were treated with VPA or RA and Hox expression assessed. Altered expression of specific Hox genes may thus account for the homeotic transformations and other malformations found in VPA-treated fetuses.

UR - http://www.scopus.com/inward/record.url?scp=0033968253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033968253&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 227

EP - 236

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 2

ER -