A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.

Raphaële Castagné; Michelle Kelly-Irving; Vittorio Krogh; Domenico Palli; Salvatore Panico; Carlotta Sacerdote; Rosario Tumino; Dennie Gaj Hebels; Jos Cs Kleinjans; Theo McM de Kok; Panagiotis Georgiadis; Soterios A. Kyrtopoulos; Roel Vermeulen; Silvia Stringhini; Paolo Vineis; Marc Chadeau-Hyam; Cyrille Delpierre

doi:10.2217/epi-2019-0261

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.

Raphaële Castagné, Michelle Kelly-Irving, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Dennie Gaj Hebels, Jos Cs Kleinjans, Theo McM de Kok, Panagiotis Georgiadis, Soterios A. Kyrtopoulos, Roel Vermeulen, Silvia Stringhini, Paolo Vineis, Marc Chadeau-Hyam, Cyrille Delpierre

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

Original language	English
Pages (from-to)	1287-1302
Number of pages	16
Journal	Epigenomics
Volume	12
Issue number	15
DOIs	https://doi.org/10.2217/epi-2019-0261
Publication status	Published - Aug 1 2020

Keywords

protein
gene expression
inflammation
DNA methylation
life course epidemiology
socioeconomic position

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Castagné, R., Kelly-Irving, M., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Hebels, D. G., Kleinjans, J. C., de Kok, T. M., Georgiadis, P., Kyrtopoulos, S. A., Vermeulen, R., Stringhini, S., Vineis, P., Chadeau-Hyam, M., & Delpierre, C. (2020). A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. Epigenomics, 12(15), 1287-1302. https://doi.org/10.2217/epi-2019-0261

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. / Castagné, Raphaële; Kelly-Irving, Michelle; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Hebels, Dennie Gaj; Kleinjans, Jos Cs; de Kok, Theo McM; Georgiadis, Panagiotis; Kyrtopoulos, Soterios A.; Vermeulen, Roel; Stringhini, Silvia; Vineis, Paolo; Chadeau-Hyam, Marc; Delpierre, Cyrille.

In: Epigenomics, Vol. 12, No. 15, 01.08.2020, p. 1287-1302.

Research output: Contribution to journal › Article › peer-review

Castagné, R, Kelly-Irving, M, Krogh, V, Palli, D, Panico, S, Sacerdote, C, Tumino, R, Hebels, DG, Kleinjans, JC, de Kok, TM, Georgiadis, P, Kyrtopoulos, SA, Vermeulen, R, Stringhini, S, Vineis, P, Chadeau-Hyam, M & Delpierre, C 2020, 'A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.', Epigenomics, vol. 12, no. 15, pp. 1287-1302. https://doi.org/10.2217/epi-2019-0261

Castagné, Raphaële ; Kelly-Irving, Michelle ; Krogh, Vittorio ; Palli, Domenico ; Panico, Salvatore ; Sacerdote, Carlotta ; Tumino, Rosario ; Hebels, Dennie Gaj ; Kleinjans, Jos Cs ; de Kok, Theo McM ; Georgiadis, Panagiotis ; Kyrtopoulos, Soterios A. ; Vermeulen, Roel ; Stringhini, Silvia ; Vineis, Paolo ; Chadeau-Hyam, Marc ; Delpierre, Cyrille. / A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. In: Epigenomics. 2020 ; Vol. 12, No. 15. pp. 1287-1302.

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abstract = "Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.",

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AU - Castagné, Raphaële

AU - Kelly-Irving, Michelle

AU - Krogh, Vittorio

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Hebels, Dennie Gaj

AU - Kleinjans, Jos Cs

AU - de Kok, Theo McM

AU - Georgiadis, Panagiotis

AU - Kyrtopoulos, Soterios A.

AU - Vermeulen, Roel

AU - Stringhini, Silvia

AU - Vineis, Paolo

AU - Chadeau-Hyam, Marc

AU - Delpierre, Cyrille

N1 - Place: England

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

AB - Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

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KW - gene expression

KW - inflammation

KW - DNA methylation

KW - life course epidemiology

KW - socioeconomic position

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JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

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ER -

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.

Abstract

Keywords

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