Abstract
Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
Original language | English |
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Pages (from-to) | 1287-1302 |
Number of pages | 16 |
Journal | Epigenomics |
Volume | 12 |
Issue number | 15 |
DOIs | |
Publication status | Published - Aug 1 2020 |
Keywords
- protein
- gene expression
- inflammation
- DNA methylation
- life course epidemiology
- socioeconomic position