A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea

G. Gasbarrini, G. R. Corazza, M. Feliciani, O. Albano, N. Stufano, E. Altomare, G. Fontana, D. Valpiani, F. Chiodo, C. Banterle

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of 1-(2,6-dimethylphenyl)-3-methylamidinourea hydrochloride (lidamidine HCl, WHR-1142 A) an aryl-substituted amidinourea recently synthesized, was compared with that of loperamide in 32 patients with acute diarrhoea. The results of the study show that lidamidine HCl and loperamide had comparable effects in the pharmacological treatment of acute non-specific diarrhoea. Lidamidine HCl was also shown to be well tolerated; side effects were generally minor and self-limiting.

Original languageEnglish
Pages (from-to)1843-1845
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume36
Issue number12
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Fingerprint Dive into the research topics of 'A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea'. Together they form a unique fingerprint.

Cite this