A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea

G. Gasbarrini; G. R. Corazza; M. Feliciani; O. Albano; N. Stufano; E. Altomare; G. Fontana; D. Valpiani; F. Chiodo; C. Banterle

A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea

G. Gasbarrini, G. R. Corazza, M. Feliciani, O. Albano, N. Stufano, E. Altomare, G. Fontana, D. Valpiani, F. Chiodo, C. Banterle

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The efficacy of 1-(2,6-dimethylphenyl)-3-methylamidinourea hydrochloride (lidamidine HCl, WHR-1142 A) an aryl-substituted amidinourea recently synthesized, was compared with that of loperamide in 32 patients with acute diarrhoea. The results of the study show that lidamidine HCl and loperamide had comparable effects in the pharmacological treatment of acute non-specific diarrhoea. Lidamidine HCl was also shown to be well tolerated; side effects were generally minor and self-limiting.

Original language	English
Pages (from-to)	1843-1845
Number of pages	3
Journal	Arzneimittel-Forschung/Drug Research
Volume	36
Issue number	12
Publication status	Published - 1986

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry
Chemistry(all)
Pharmacology

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A multicenter double-blind controlled trial comparing lidamidine HCl and loperamide in the symptomatic treatment of acute diarrhoea. / Gasbarrini, G.; Corazza, G. R.; Feliciani, M.; Albano, O.; Stufano, N.; Altomare, E.; Fontana, G.; Valpiani, D.; Chiodo, F.; Banterle, C.

In: Arzneimittel-Forschung/Drug Research, Vol. 36, No. 12, 1986, p. 1843-1845.

Research output: Contribution to journal › Article › peer-review

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AU - Albano, O.

AU - Stufano, N.

AU - Altomare, E.

AU - Fontana, G.

AU - Valpiani, D.

AU - Chiodo, F.

AU - Banterle, C.

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AB - The efficacy of 1-(2,6-dimethylphenyl)-3-methylamidinourea hydrochloride (lidamidine HCl, WHR-1142 A) an aryl-substituted amidinourea recently synthesized, was compared with that of loperamide in 32 patients with acute diarrhoea. The results of the study show that lidamidine HCl and loperamide had comparable effects in the pharmacological treatment of acute non-specific diarrhoea. Lidamidine HCl was also shown to be well tolerated; side effects were generally minor and self-limiting.

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