A multicenter Italian randomised study on early treatment of Parkinson disease: comparison of 1-dopa, 1-deprenyl and dopaminoagonists. Study design and short term results

T. Caraceni, M. Musicco, M. Gasparini, E. Beghi, G. Scigliano, F. Carella, E. Cossutta, C. Chiaro, G. Lovicu, G. Giminiani, I. Currado, A. Solari, A. Nicolosi, A. Agnoli, G. Nappi, G. Giuliani, A. Angeleri, G. Moro, A. Franciosi, M. De MariP. Lamberti, R. Huber, G. Coppola, G. Trianni, M. Onofri, L. Curatola, E. Paolino, I. Casetta, P. Scaglioni, P. Caffarra, P. Marini, P. Vanni, S. Genitrini, R. Sterzi, M. Ferrarini, P. Bassi, P. Contri, G. C. Comi, M. Comola, G. Campanella, G. De Michele, C. Pacchetti, E. Martignoni, M. Piccirilli, G. Finali, R. Massetani, R. Galli, A. Albanese, A. Bentivoglio, C. Scoppetta, A. Peppe, P. Stanzione, R. Semprini, F. Rossi, A. Castellano, R. Marconi, E. Fincati, G. Tomelleri, E. Nardelli, G. Nordera, F. Iemolo, G. D'Asta, A. Lorizio, F. Salsa, R. Freschi, S. Meregalli, S. Bandinelli, S. Gangemi, L. Capus, P. Piola, G. Bino, P. Achille, M. Pederzoli, G. L. Lenzi

Research output: Contribution to journalArticlepeer-review

Abstract

On the long term Parkinson Disease (PD) treatment is often complicated by the occurrence of motor fluctuations. To find out whether early treatment of PD with levodopa, dopaminoagonists or 1-deprenyl is associated with any difference in motor fluctuations occurrence, the Italian Parkinson Study Groups initiated a multicenter, randomized study. Since November 1988, 475 patients cequiring effective treatment for idiopathic PD have been randomized to receive levodopa, dopoamine agonists or deprenyl. After 2 months of therapy, all patients evaluated with the Unified Parkinson Disease Rating Scale showed a significant amelioration. Daily living activities were more impaired in patients treated with deprenyl. Study design is presented and first resuts are discussed.

Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalItalian Journal of Neurological Sciences
Volume13
Issue number9
DOIs
Publication statusPublished - Dec 1992

Keywords

  • motor fluctuation
  • Parkinson disease
  • prognosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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