TY - JOUR
T1 - A multicenter randomized, controlled study comparing laparoscopic versus minilaparotomic myomectomy
T2 - reproductive outcomes
AU - Palomba, Stefano
AU - Zupi, Errico
AU - Falbo, Angela
AU - Russo, Tiziana
AU - Marconi, Daniela
AU - Tolino, Achille
AU - Manguso, Francesco
AU - Mattei, Alberto
AU - Zullo, Fulvio
PY - 2007/10
Y1 - 2007/10
N2 - Objective: To assess the reproductive outcomes after minilaparotomic and laparoscopic myomectomy in patients wishing to conceive. Design: Randomized controlled trial. Setting: Departments of obstetrics and gynecology of the universities of Catanzaro, Rome, and Florence, Italy. Patient(s): One hundred thirty-six women with symptomatic uterine leiomyomas or unexplained infertility. Intervention(s): Laparoscopic and minilaparotomic myomectomy. Main Outcome Measure(s): Pregnancy, abortion, and live-birth rates. Result(s): Between the laparoscopic and minilaparotomic groups no difference was observed in cumulative pregnancy, live-birth, and abortion rates, whereas pregnancy and live-birth rates per cycle, and time to first pregnancy and live-birth were significantly higher in the laparoscopic than in the minilaparotomic group. Categorizing the patients according to surgical indication for myomectomy, cumulative pregnancy rate, pregnancy, and live-birth rates per cycle, and time to first pregnancy and live-birth were significantly better after laparoscopic myomectomy in symptomatic patients, whereas all reproductive outcomes were similar between the two groups in patients with unexplained infertility. Conclusion(s): Minilaparotomic and laparoscopic myomectomy improves in a similar manner the reproductive outcomes in patients with unexplained infertility, whereas the laparoscopic approach provides the best benefits in fertile patients with symptomatic leiomyomas.
AB - Objective: To assess the reproductive outcomes after minilaparotomic and laparoscopic myomectomy in patients wishing to conceive. Design: Randomized controlled trial. Setting: Departments of obstetrics and gynecology of the universities of Catanzaro, Rome, and Florence, Italy. Patient(s): One hundred thirty-six women with symptomatic uterine leiomyomas or unexplained infertility. Intervention(s): Laparoscopic and minilaparotomic myomectomy. Main Outcome Measure(s): Pregnancy, abortion, and live-birth rates. Result(s): Between the laparoscopic and minilaparotomic groups no difference was observed in cumulative pregnancy, live-birth, and abortion rates, whereas pregnancy and live-birth rates per cycle, and time to first pregnancy and live-birth were significantly higher in the laparoscopic than in the minilaparotomic group. Categorizing the patients according to surgical indication for myomectomy, cumulative pregnancy rate, pregnancy, and live-birth rates per cycle, and time to first pregnancy and live-birth were significantly better after laparoscopic myomectomy in symptomatic patients, whereas all reproductive outcomes were similar between the two groups in patients with unexplained infertility. Conclusion(s): Minilaparotomic and laparoscopic myomectomy improves in a similar manner the reproductive outcomes in patients with unexplained infertility, whereas the laparoscopic approach provides the best benefits in fertile patients with symptomatic leiomyomas.
KW - Fertility
KW - fibroid
KW - infertility
KW - laparoscopy
KW - leiomyomas
KW - minilaparotomy
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U2 - 10.1016/j.fertnstert.2006.12.047
DO - 10.1016/j.fertnstert.2006.12.047
M3 - Article
C2 - 17434505
AN - SCOPUS:34848837332
VL - 88
SP - 933
EP - 941
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 4
ER -