A multicenter retrospective clinical study of CD5/CD10-negative chronic B cell leukemias

Maria Cecilia Goldaniga, Andrea Ferrario, Sergio Cortelazzo, Andrea Guffanti, Enzo Pavone, Achille Ambrosetti, Luigi Marcheselli, Francesca Rossi, Stefano Luminari, Andrea Rossi, Lilla Cro, Massimo Federico, Giorgio Lambertenghi Deliliers, Luca Baldini

Research output: Contribution to journalArticlepeer-review

Abstract

CD5-negative chronic B cell lymphoproliferative disorders in leukemic phase (B-CLPD) are heterogeneous and relatively uncommon pathologies that often lack a histopathological definition because of the absence of accessible pathological tissue. We describe the clinical features and evolution-related variables of 156 patients with CD5/CD10-negative B-CLPD (median age 66 years, range 25-86). The median follow-up was 51 months (range 6-216), and overall 3- and 5-year survival was respectively 87 and 76%; 50 patients needed therapy at diagnosis, 56 during follow-up, and 50 remained untreated until the last control. A combined clinical, histological, cytomorphological, immunophenotypical, and cytogenetic diagnostic approach allowed the complete classification of only a minority of patients as being affected by splenic marginal zone or lymphoplasmacytic lymphoma; the majority of cases remained unclassifiable. Multivariate analysis showed that the clinicohematological variables adversely related to overall survival were serum LDH levels and age, whereas high serum LDH levels, hemoglobin levels of

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalAmerican Journal of Hematology
Volume83
Issue number5
DOIs
Publication statusPublished - May 2008

ASJC Scopus subject areas

  • Hematology

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