A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band

Diana Ferraro, Diego Franciotta, Roberta Bedin, Claudio Solaro, Eleonora Cocco, Mario Santangelo, Paolo Immovilli, Alberto Gajofatto, Massimiliano Calabrese, Massimiliano Di Filippo, Riccardo Orlandi, Anna Maria Simone, Francesca Vitetta, Elisabetta Capello, Debora Giunti, Alessandra Murialdo, Jessica Frau, Sara Mariotto, Antongiulio Gallina, Claudio GasperiniPatrizia Sola, On behalf of the RIREMS group (Rising Italian Researchers in Multiple Sclerosis)

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The analysis of paired cerebrospinal fluid (CSF) and serum samples with isolectric focusing (IEF) can yield different patterns which can be of aid in the differential diagnosis of central nervous system (CNS) disorders. Rarely, a single CSF-restricted IgG band, which is not included within these patterns, can be detected in association with inflammatory disorders, multiple sclerosis (MS) above all. However, the diagnostic meaning of this abnormality is still uncertain. The main aim of our multicenter study was to establish the frequency and disease associations of single CSF IgG bands. Differences in the CSF profiles between MS and other diseases, and the follow-up patterns were also evaluated. Medical records of patients who underwent CSF analysis, which included IEF, over a 11.5-year period were retrospectively scrutinized at the participating centers, which used similar IEF techniques. One hundred and fifty-one of 9422 CSF reports (1.6%) showed single CSF-restricted IgG bands. Of the 129 patients with a definite diagnosis, 58.2% had CNS inflammatory-demyelinating diseases (the most frequent being MS: 21.7%), 6.2% tumours, 5.4% inflammatory peripheral nervous system diseases and 30.2% miscellaneous diseases. At follow-up, 3 out of the 10 patients with a repeated CSF analysis had developed an oligoclonal band pattern. Our findings indicate that single CSF IgG bands tend to associate with diseases characterized by the involvement of intrathecal humoral immune responses, and strongly support the notion that this abnormality should be regularly reported, thus alerting clinicians of possible inflammatory disorders of the CNS.

Original languageEnglish
Pages (from-to)973-978
Number of pages6
JournalJournal of Neurology
Volume264
Issue number5
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Multicenter Studies
Cerebrospinal Fluid
Immunoglobulin G
Multiple Sclerosis
Central Nervous System Diseases
Oligoclonal Bands
Demyelinating Diseases
Peripheral Nervous System Diseases
Humoral Immunity
Medical Records
Differential Diagnosis
Central Nervous System
Serum
Neoplasms

Keywords

  • Cerebrospinal fluid
  • Isoelectric focusing
  • Multiple sclerosis
  • Single IgG band

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Ferraro, D., Franciotta, D., Bedin, R., Solaro, C., Cocco, E., Santangelo, M., ... On behalf of the RIREMS group (Rising Italian Researchers in Multiple Sclerosis) (2017). A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band. Journal of Neurology, 264(5), 973-978. https://doi.org/10.1007/s00415-017-8480-5

A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band. / Ferraro, Diana; Franciotta, Diego; Bedin, Roberta; Solaro, Claudio; Cocco, Eleonora; Santangelo, Mario; Immovilli, Paolo; Gajofatto, Alberto; Calabrese, Massimiliano; Di Filippo, Massimiliano; Orlandi, Riccardo; Simone, Anna Maria; Vitetta, Francesca; Capello, Elisabetta; Giunti, Debora; Murialdo, Alessandra; Frau, Jessica; Mariotto, Sara; Gallina, Antongiulio; Gasperini, Claudio; Sola, Patrizia; On behalf of the RIREMS group (Rising Italian Researchers in Multiple Sclerosis).

In: Journal of Neurology, Vol. 264, No. 5, 01.05.2017, p. 973-978.

Research output: Contribution to journalArticle

Ferraro, D, Franciotta, D, Bedin, R, Solaro, C, Cocco, E, Santangelo, M, Immovilli, P, Gajofatto, A, Calabrese, M, Di Filippo, M, Orlandi, R, Simone, AM, Vitetta, F, Capello, E, Giunti, D, Murialdo, A, Frau, J, Mariotto, S, Gallina, A, Gasperini, C, Sola, P & On behalf of the RIREMS group (Rising Italian Researchers in Multiple Sclerosis) 2017, 'A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band', Journal of Neurology, vol. 264, no. 5, pp. 973-978. https://doi.org/10.1007/s00415-017-8480-5
Ferraro D, Franciotta D, Bedin R, Solaro C, Cocco E, Santangelo M et al. A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band. Journal of Neurology. 2017 May 1;264(5):973-978. https://doi.org/10.1007/s00415-017-8480-5
Ferraro, Diana ; Franciotta, Diego ; Bedin, Roberta ; Solaro, Claudio ; Cocco, Eleonora ; Santangelo, Mario ; Immovilli, Paolo ; Gajofatto, Alberto ; Calabrese, Massimiliano ; Di Filippo, Massimiliano ; Orlandi, Riccardo ; Simone, Anna Maria ; Vitetta, Francesca ; Capello, Elisabetta ; Giunti, Debora ; Murialdo, Alessandra ; Frau, Jessica ; Mariotto, Sara ; Gallina, Antongiulio ; Gasperini, Claudio ; Sola, Patrizia ; On behalf of the RIREMS group (Rising Italian Researchers in Multiple Sclerosis). / A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band. In: Journal of Neurology. 2017 ; Vol. 264, No. 5. pp. 973-978.
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AU - Bedin, Roberta

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AU - Santangelo, Mario

AU - Immovilli, Paolo

AU - Gajofatto, Alberto

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AU - Di Filippo, Massimiliano

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AU - Murialdo, Alessandra

AU - Frau, Jessica

AU - Mariotto, Sara

AU - Gallina, Antongiulio

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AU - Sola, Patrizia

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