A multicentre European registry of intraluminal coronary beta brachytherapy

Philip Urban, P. Serruys, D. Baumgart, A. Colombo, S. Silber, E. Eeckhout, A. Gershlick, K. Wegscheider, L. Verhees, R. Bonan

Research output: Contribution to journalArticle

Abstract

Aims: To assess the feasibility, safety and effectiveness of intravascular brachytherapy (VBT) in routine clinical practice. Methods and results: Between April 1999 and September 2000, 1098 consecutive patients treated in 46 European centres by intraluminal irradiation using a Sr/Y90 source train (BetaCath™, Novoste, GA) were included in a registry, and follow-up data were obtained for 98.8% of them after 6.3±2.4 months. Eight hundred and forty (76.5%) patients were males, and mean age was 62.0±10.2 years. Two hundred and seventy-one (26.9%) had unstable angina, and 256 (23.5%) were diabetics. Nine hundred and thirteen lesions (77.7%) were the result of in-stent restenosis, 208 (17.7%) were de novo lesions and 48 (4.1%) non-stented restenotic lesions. Mean estimated reference diameter was 3.2±0.5 mm and mean estimated lesion length was 19.0±11.8 mm. The prescribed radiation dose was 18.8±3.2 Gy. Multivessel irradiation was done in 6.2% of cases, and a new stent was implanted in 29.6% of cases. Most patients received 6 or 12 months of combined aspirin and thienopyridin treatment after the procedure. Technical success was obtained in 95.9% of treated lesions, and the in-hospital major adverse cardiac event (MACE) rate was 1.8%. At follow-up, the MACE rate was 18.7% (1.9% deaths from any cause, 2.6% AMI, 13.3% TVR by PCI and 3.3% TVR by CABG). Conclusion: The major current application of VBT is the treatment of in-stent restenosis. The good results of VBT observed in recent randomized controlled trials can be reproduced in clinical practice.

Original languageEnglish
Pages (from-to)604-612
Number of pages9
JournalEuropean Heart Journal
Volume24
Issue number7
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Irradiation
  • Restenosis
  • Stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Urban, P., Serruys, P., Baumgart, D., Colombo, A., Silber, S., Eeckhout, E., Gershlick, A., Wegscheider, K., Verhees, L., & Bonan, R. (2003). A multicentre European registry of intraluminal coronary beta brachytherapy. European Heart Journal, 24(7), 604-612. https://doi.org/10.1016/S0195-668X(02)00617-6