A multicentre evaluation of dosiomics features reproducibility, stability and sensitivity

Lorenzo Placidi, Eliana Gioscio, Cristina Garibaldi, Tiziana Rancati, Annarita Fanizzi, Davide Maestri, Raffaella Massafra, Enrico Menghi, Alfredo Mirandola, Giacomo Reggiori, Roberto Sghedoni, Pasquale Tamborra, Stefania Comi, Jacopo Lenkowicz, Luca Boldrini, Michele Avanzo

Research output: Contribution to journalArticlepeer-review


Dosiomics is a texture analysis method to produce dose features that encode the spatial 3D distribution of radiotherapy dose. Dosiomic studies, in a multicentre setting, require assessing the features’ stability to dose calculation settings and the features’ capability in distinguishing different dose distributions. Dose distributions were generated by eight Italian centres on a shared image dataset acquired on a dedicated phantom. Treatment planning protocols, in terms of planning target volume coverage and dose–volume constraints to the organs at risk, were shared among the centres to produce comparable dose distributions for measuring reproducibility/stability and sensitivity of dosiomic features. In addition, coefficient of variation (CV) was employed to evaluate the dosiomic features’ variation. We extracted 38,160 features from 30 different dose distributions from six regions of interest, grouped by four features’ families. A selected group of features (CV < 3 for the reproducibility/stability studies, CV > 1 for the sensitivity studies) were identified to support future multicentre studies, assuring both stable features when dose distributions variation is minimal and sensitive features when dose distribution variations need to be clearly identified. Dosiomic is a promising tool that could support multicentre studies, especially for predictive models, and encode the spatial and statistical characteristics of the 3D dose distribution.

Original languageEnglish
Article number3835
Issue number15
Publication statusPublished - Jul 30 2021


  • Dose distribution texture analysis
  • Dosiomics
  • Multicentric study
  • Radiation dosimetry
  • Radiotherapy
  • Reproducibility
  • Sensitivity
  • Stability

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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