A multicentric phase II clinical trial on intra-arterial hepatic radiotherapy with 90Yttrium SIR-spheres in unresectable, colorectal liver metastases refractory to i.v. chemotherapy: Preliminary results on toxicity and response rates

R. Mancini, L. Carpanese, R. Sciuto, G. Pizzi, R. Golfieri, L. Giampalma, A. Cappelli, M. C. Galaverni, A. Blotta, F. Fiore, F. Izzo, S. Lastoria, A. Mastro, M. Di Marzo, P. P. Cagol, D. Gasparini, O. Geatti, S. Bacchetti, E. Pasqual, M. ZeuliG. Paoletti, C. Garufi, Maurizio Cosimelli

Research output: Contribution to journalArticle

Abstract

Background: In patients locally progressing after two lines of chemotherapy, some locoregional approaches showed encouraging results in terms of local control of disease. The aim of our study was to evaluate toxicity, clinical response and quality of life in 48 patients with unresectable colorectal liver metastases submitted to selective internal radiotherapy (SIRT). Materials and Methods: Up to now 35 patients with unresectable colorectal liver metastases, refractory to two lines of chemotherapy, underwent intra-arterial infusion of resin microspheres with yttrium-90 (SIR-spheres). Pre-treatment evaluation included a CT scan, blood tests, a PET scan and arteriography of celiac trunk, hepatic and superior mesenteric artery; extrahepatic uptakes and pulmonary shunts more than 10% were excluded by a Scinti-scan. The gastroduodenal artery was embolized before the SIR-spheres injection. Other exclusion criteria were liver dysfunction and anatomical vascular anomalies. The clinical response was evaluated by CT-scan following the RECIST criteria. Median follow-up was 4 months. Results: Median number of metastases was 4 (range, 1-15), 38% of cases presenting hepatic involvement

Original languageEnglish
Pages (from-to)711-714
Number of pages4
JournalIn Vivo
Volume20
Issue number6 A
Publication statusPublished - Nov 2006

Keywords

  • Colorectal liver metastases
  • Locoregional therapies
  • SIRT

ASJC Scopus subject areas

  • Medicine(all)

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    Mancini, R., Carpanese, L., Sciuto, R., Pizzi, G., Golfieri, R., Giampalma, L., Cappelli, A., Galaverni, M. C., Blotta, A., Fiore, F., Izzo, F., Lastoria, S., Mastro, A., Di Marzo, M., Cagol, P. P., Gasparini, D., Geatti, O., Bacchetti, S., Pasqual, E., ... Cosimelli, M. (2006). A multicentric phase II clinical trial on intra-arterial hepatic radiotherapy with 90Yttrium SIR-spheres in unresectable, colorectal liver metastases refractory to i.v. chemotherapy: Preliminary results on toxicity and response rates. In Vivo, 20(6 A), 711-714.