TY - JOUR
T1 - A multicentric study on accurate grading of prostate cancer with systematic and MRI/US fusion targeted biopsies
T2 - comparison with final histopathology after radical prostatectomy
AU - Diamand, R.
AU - Oderda, M.
AU - Al Hajj Obeid, W.
AU - Albisinni, S.
AU - Van Velthoven, R.
AU - Fasolis, G.
AU - Simone, G.
AU - Ferriero, M.
AU - Roche, J. B.
AU - Piechaud, T.
AU - Pastore, A.
AU - Carbone, A.
AU - Fiard, G.
AU - Descotes, J. L.
AU - Marra, G.
AU - Gontero, P.
AU - Altobelli, E.
AU - Papalia, R.
AU - Kumar, P.
AU - Eldred-Evans, D.
AU - Giacobbe, A.
AU - Muto, G.
AU - Lacetera, V.
AU - Beatrici, V.
AU - Roumeguere, T.
AU - Peltier, A.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Objective: To evaluate the accuracy in histologic grading of MRI/US image fusion biopsy by comparing histopathology between systematic biopsies (SB), targeted biopsies (TB) and the combination of both (SB + TB) with the final histopathologic outcomes of radical prostatectomy specimens. Materials and methods: Retrospective, multicentric study of 443 patients who underwent SB and TB using MRI/US fusion technique (Urostation® and Trinity®) prior to radical prostatectomy between 2010 and 2017. Cochran’s Q test and McNemar test were conducted as a post hoc test. Uni-multivariable analyses were performed on several clinic-pathological variables to analyze factors predicting histopathological concordance for targeted biopsies. Results: Concordance in ISUP (International Society of Urological Pathology) grade between SB, TB and SB + TB with final histopathology was 49.4%, 51.2%, and 63.2% for overall prostate cancer and 41.2%, 48.3%, and 56.7% for significant prostate cancer (ISUP grade ≥ 2), respectively. Significant difference in terms of concordance, downgrading and upgrading was found between SB and TB (ISUP grade ≥ 2 only), SB and SB + TB, TB and SB + TB (overall ISUP grade and ISUP grade ≥ 2) (p < 0.001). Total number of cores and previous biopsies were significant independent predictive factors for concordance with TB technique. Conclusion: In this retrospective study, combination of SB and TB significantly increased concordance with final histopathology despite a limited additional number of cores needed.
AB - Objective: To evaluate the accuracy in histologic grading of MRI/US image fusion biopsy by comparing histopathology between systematic biopsies (SB), targeted biopsies (TB) and the combination of both (SB + TB) with the final histopathologic outcomes of radical prostatectomy specimens. Materials and methods: Retrospective, multicentric study of 443 patients who underwent SB and TB using MRI/US fusion technique (Urostation® and Trinity®) prior to radical prostatectomy between 2010 and 2017. Cochran’s Q test and McNemar test were conducted as a post hoc test. Uni-multivariable analyses were performed on several clinic-pathological variables to analyze factors predicting histopathological concordance for targeted biopsies. Results: Concordance in ISUP (International Society of Urological Pathology) grade between SB, TB and SB + TB with final histopathology was 49.4%, 51.2%, and 63.2% for overall prostate cancer and 41.2%, 48.3%, and 56.7% for significant prostate cancer (ISUP grade ≥ 2), respectively. Significant difference in terms of concordance, downgrading and upgrading was found between SB and TB (ISUP grade ≥ 2 only), SB and SB + TB, TB and SB + TB (overall ISUP grade and ISUP grade ≥ 2) (p < 0.001). Total number of cores and previous biopsies were significant independent predictive factors for concordance with TB technique. Conclusion: In this retrospective study, combination of SB and TB significantly increased concordance with final histopathology despite a limited additional number of cores needed.
KW - Biopsy
KW - Concordance
KW - MRI/US fusion
KW - Prostate cancer
KW - Targeted
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U2 - 10.1007/s00345-019-02634-9
DO - 10.1007/s00345-019-02634-9
M3 - Article
C2 - 30652213
AN - SCOPUS:85060146030
VL - 37
SP - 2109
EP - 2117
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 10
ER -