A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years.

Elizaveta Kon; Giuseppe Filardo; Mats Brittberg; Maurizio Busacca; Vincenzo Condello; Lars  Engebretsen; Stefan  Marlovits; Philipp Niemeyer; Patrik  Platzer; Michael  Posthumus; Peter  Verdonk; Renè  Verdonk; Jan Victor; Willem van der Merwe; Wojciech  Widuchowski; Claudio Zorzi; Maurilio Marcacci

doi:10.1007/s00167-017-4707-3

A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years.

Elizaveta Kon, Giuseppe Filardo, Mats Brittberg, Maurizio Busacca, Vincenzo Condello, Lars Engebretsen, Stefan Marlovits, Philipp Niemeyer, Patrik Platzer, Michael Posthumus, Peter Verdonk, Renè Verdonk, Jan Victor, Willem van der Merwe, Wojciech Widuchowski, Claudio Zorzi, Maurilio Marcacci

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The increasing awareness on the role of subchondral
bone in the etiopathology of articular surface lesions
led to the development of osteochondral scafolds. While
safety and promising results have been suggested, there
are no trials proving the real potential of the osteochondral
regenerative approach. Aim was to assess the beneft provided
by a nanostructured collagen–hydroxyapatite (collHA)
multilayer scafold for the treatment of chondral and
osteochondral knee lesions.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Knee Surgery, Sports Traumatology, Arthroscopy
DOIs	https://doi.org/10.1007/s00167-017-4707-3
Publication status	Published - Sep 14 2017

Keywords

Bone marrow stimulation
Cartilage
Knee
Osteochondral
Scaffold

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10.1007/s00167-017-4707-3

Cite this

Kon, E., Filardo, G., Brittberg, M., Busacca, M., Condello, V., Engebretsen, L., Marlovits, S., Niemeyer, P., Platzer, P., Posthumus, M., Verdonk, P., Verdonk, R., Victor, J., van der Merwe, W., Widuchowski, W., Zorzi, C., & Marcacci, M. (2017). A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years. Knee Surgery, Sports Traumatology, Arthroscopy, 1-12. https://doi.org/10.1007/s00167-017-4707-3

A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years. / Kon, Elizaveta; Filardo, Giuseppe; Brittberg, Mats et al.

In: Knee Surgery, Sports Traumatology, Arthroscopy, 14.09.2017, p. 1-12.

Research output: Contribution to journal › Article › peer-review

Kon, E, Filardo, G, Brittberg, M, Busacca, M, Condello, V, Engebretsen, L, Marlovits, S, Niemeyer, P, Platzer, P, Posthumus, M, Verdonk, P, Verdonk, R, Victor, J, van der Merwe, W, Widuchowski, W, Zorzi, C & Marcacci, M 2017, 'A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years.', Knee Surgery, Sports Traumatology, Arthroscopy, pp. 1-12. https://doi.org/10.1007/s00167-017-4707-3

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abstract = "The increasing awareness on the role of subchondralbone in the etiopathology of articular surface lesionsled to the development of osteochondral scafolds. Whilesafety and promising results have been suggested, thereare no trials proving the real potential of the osteochondralregenerative approach. Aim was to assess the beneft providedby a nanostructured collagen–hydroxyapatite (collHA)multilayer scafold for the treatment of chondral andosteochondral knee lesions.",

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AU - Brittberg, Mats

AU - Busacca, Maurizio

AU - Condello, Vincenzo

AU - Engebretsen, Lars

AU - Marlovits, Stefan

AU - Niemeyer, Philipp

AU - Platzer, Patrik

AU - Posthumus, Michael

AU - Verdonk, Peter

AU - Verdonk, Renè

AU - Victor, Jan

AU - van der Merwe, Willem

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AU - Zorzi, Claudio

AU - Marcacci, Maurilio

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AB - The increasing awareness on the role of subchondralbone in the etiopathology of articular surface lesionsled to the development of osteochondral scafolds. Whilesafety and promising results have been suggested, thereare no trials proving the real potential of the osteochondralregenerative approach. Aim was to assess the beneft providedby a nanostructured collagen–hydroxyapatite (collHA)multilayer scafold for the treatment of chondral andosteochondral knee lesions.

KW - Bone marrow stimulation

KW - Cartilage

KW - Knee

KW - Osteochondral

KW - Scaffold

U2 - 10.1007/s00167-017-4707-3

DO - 10.1007/s00167-017-4707-3

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JO - Knee Surgery, Sports Traumatology, Arthroscopy

JF - Knee Surgery, Sports Traumatology, Arthroscopy

SN - 0942-2056

ER -

A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years.

Abstract

Keywords

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