A multimodal approach to the study of children treated for posterior fossa tumor: A review of the literature and a pilot study

Tiziana Zilli, Valentina Dolcemascolo, Eva Passone, Marta Maieron, Maria Cristina De Colle, Miran Skrap, Tamara Ius, Ilaria Liguoro, Martina Venchiarutti, Paola Cogo, Barbara Tomasino

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aims of the present study were: (1) to review the literature on long-lasting cognitive sequelae in children treated for Posterior Fossa Tumor and (2) to investigate anatomic functional relations in a case series of 7 children treated for PFT using magnetic resonance imaging (MRI) post-processing methods. Methods: We retrospectively analyzed MRIs of children who underwent complete surgical resection of PFT and performed extensive neuropsychological evaluation. Tumor, ventricular volumes, and VPS insertion site were drawn on T1 volumetric MRI scans and normalized to a pediatric template. Children showed worse performances on tasks tapping executive functions, memory, visuo-motor precision, and expressive language. Results: Volumes of interest related to these functions showed a maximum overlap on the left vermis and the lateral ventricle enlargement, except for impaired narrative fluency –which was associated with left lateral ventricle enlargement– and narrative memory –which was related to the right vermis and the enlarged fourth ventricle. Conclusion: Results suggest that anatomic functional relations in children treated for PFT are related to a combination of different pathophysiological factors.

Original languageEnglish
Article number106819
Number of pages10
JournalClinical Neurology and Neurosurgery
Volume207
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Children
  • MRI
  • Neuropsychology
  • Posterior fossa tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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