A multimodal imaging approach to the evaluation of post-traumatic epilepsy

Silvia F. Storti, Emanuela Formaggio, Enrica Franchini, Luigi G. Bongiovanni, Roberto Cerini, Antonio Fiaschi, Christoph M. Michel, Paolo Manganotti

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Object Electroencephalography-functional magnetic resonance imaging (EEG-fMRI) coregistration and high-density EEG (hdEEG) can be combined to map noninvasively abnormal brain activation elicited by epileptic processes. By combining noninvasive imaging techniques in a multimodal approach, we sought to investigate pathophysiological mechanisms underlying epileptic activity in seven patients with severe traumatic brain injury. Materials and methods Standard EEG and fMRI data were acquired during a single scanning session. The EEGfMRI data were analyzed using the general linear model and independent component analysis. Source localization of interictal epileptiform discharges (IEDs) was performed using 256-channel hdEEG. Blood oxygenation level dependent (BOLD) localizations were then compared to EEG source reconstruction. Results On hdEEG, focal source localization was detected in all seven patients; in six out of seven it was concordant with the expected epileptic activity as defined by EEG data and clinical evaluation; and in four out of seven in whom IEDs were recorded, BOLD signal changes were observed. These activities were partially concordant with the source localization. Conclusion Multimodal integration of EEG-fMRI and hdEEG combining two different methods to localize the same epileptic foci appears to be a promising tool to noninvasively map abnormal brain activation in patients with post-traumatic brain injury.

Original languageEnglish
Pages (from-to)345-360
Number of pages16
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Volume25
Issue number5
DOIs
Publication statusPublished - Oct 2012

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Post-Traumatic Epilepsy
Multimodal Imaging
Electroencephalography
Magnetic Resonance Imaging
Brain
Linear Models

Keywords

  • EEG-fMRI
  • Post-traumatic epilepsy
  • Source localization

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Storti, S. F., Formaggio, E., Franchini, E., Bongiovanni, L. G., Cerini, R., Fiaschi, A., ... Manganotti, P. (2012). A multimodal imaging approach to the evaluation of post-traumatic epilepsy. Magnetic Resonance Materials in Physics, Biology, and Medicine, 25(5), 345-360. https://doi.org/10.1007/s10334-012-0316-9

A multimodal imaging approach to the evaluation of post-traumatic epilepsy. / Storti, Silvia F.; Formaggio, Emanuela; Franchini, Enrica; Bongiovanni, Luigi G.; Cerini, Roberto; Fiaschi, Antonio; Michel, Christoph M.; Manganotti, Paolo.

In: Magnetic Resonance Materials in Physics, Biology, and Medicine, Vol. 25, No. 5, 10.2012, p. 345-360.

Research output: Contribution to journalArticle

Storti, SF, Formaggio, E, Franchini, E, Bongiovanni, LG, Cerini, R, Fiaschi, A, Michel, CM & Manganotti, P 2012, 'A multimodal imaging approach to the evaluation of post-traumatic epilepsy', Magnetic Resonance Materials in Physics, Biology, and Medicine, vol. 25, no. 5, pp. 345-360. https://doi.org/10.1007/s10334-012-0316-9
Storti, Silvia F. ; Formaggio, Emanuela ; Franchini, Enrica ; Bongiovanni, Luigi G. ; Cerini, Roberto ; Fiaschi, Antonio ; Michel, Christoph M. ; Manganotti, Paolo. / A multimodal imaging approach to the evaluation of post-traumatic epilepsy. In: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2012 ; Vol. 25, No. 5. pp. 345-360.
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