Abstract
The subventricular zone (SVZ) is a region that lies immediately beneath the ependymal layer on the lateral wall of the lateral ventricles, and is separated from the caudate nucleus by a layer of myelin. It contains multipotent neural stem cells. The aim of this study was to investigate the tissue around the SVZ, with the hypothesis that multimodal MRI is able to highlight the progressive disruption of tissue caused by the neurodegenerative disease in this area. We combined volumetric and diffusion tensor (DTI) imaging using a 3 T imager in a cross-sectional study including 30 patients with amnestic-mild cognitive impairment (a-MCI), 30 patients with Alzheimer's disease (AD) and 30 age- and gender-matched healthy controls (HC). Our data indicate that mean diffusivity (MD) values increase continuously from HC through a-MCI to AD in the bilateral SVZ, where most of the proliferating stem cells in the adult brain are located. This result was specific for the SVZ and could not be observed in other periventricular areas. Multimodal MRI, being able to highlight structural changes of microscopic tissue in humans in vivo, could represent a precious tool to complement histological studies of neurogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 214-218 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 469 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 22 2010 |
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Keywords
- Alzheimer's disease
- DTI
- Mild cognitive impairment
- Subventricular zone
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients. / Cherubini, Andrea; Spoletini, Ilaria; Péran, Patrice; Luccichenti, Giacomo; Di Paola, Margherita; Sancesario, Giuseppe; Gianni, Walter; Giubilei, Franco; Bossù, Paola; Sabatini, Umberto; Caltagirone, Carlo; Spalletta, Gianfranco.
In: Neuroscience Letters, Vol. 469, No. 2, 22.01.2010, p. 214-218.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients
AU - Cherubini, Andrea
AU - Spoletini, Ilaria
AU - Péran, Patrice
AU - Luccichenti, Giacomo
AU - Di Paola, Margherita
AU - Sancesario, Giuseppe
AU - Gianni, Walter
AU - Giubilei, Franco
AU - Bossù, Paola
AU - Sabatini, Umberto
AU - Caltagirone, Carlo
AU - Spalletta, Gianfranco
PY - 2010/1/22
Y1 - 2010/1/22
N2 - The subventricular zone (SVZ) is a region that lies immediately beneath the ependymal layer on the lateral wall of the lateral ventricles, and is separated from the caudate nucleus by a layer of myelin. It contains multipotent neural stem cells. The aim of this study was to investigate the tissue around the SVZ, with the hypothesis that multimodal MRI is able to highlight the progressive disruption of tissue caused by the neurodegenerative disease in this area. We combined volumetric and diffusion tensor (DTI) imaging using a 3 T imager in a cross-sectional study including 30 patients with amnestic-mild cognitive impairment (a-MCI), 30 patients with Alzheimer's disease (AD) and 30 age- and gender-matched healthy controls (HC). Our data indicate that mean diffusivity (MD) values increase continuously from HC through a-MCI to AD in the bilateral SVZ, where most of the proliferating stem cells in the adult brain are located. This result was specific for the SVZ and could not be observed in other periventricular areas. Multimodal MRI, being able to highlight structural changes of microscopic tissue in humans in vivo, could represent a precious tool to complement histological studies of neurogenesis.
AB - The subventricular zone (SVZ) is a region that lies immediately beneath the ependymal layer on the lateral wall of the lateral ventricles, and is separated from the caudate nucleus by a layer of myelin. It contains multipotent neural stem cells. The aim of this study was to investigate the tissue around the SVZ, with the hypothesis that multimodal MRI is able to highlight the progressive disruption of tissue caused by the neurodegenerative disease in this area. We combined volumetric and diffusion tensor (DTI) imaging using a 3 T imager in a cross-sectional study including 30 patients with amnestic-mild cognitive impairment (a-MCI), 30 patients with Alzheimer's disease (AD) and 30 age- and gender-matched healthy controls (HC). Our data indicate that mean diffusivity (MD) values increase continuously from HC through a-MCI to AD in the bilateral SVZ, where most of the proliferating stem cells in the adult brain are located. This result was specific for the SVZ and could not be observed in other periventricular areas. Multimodal MRI, being able to highlight structural changes of microscopic tissue in humans in vivo, could represent a precious tool to complement histological studies of neurogenesis.
KW - Alzheimer's disease
KW - DTI
KW - Mild cognitive impairment
KW - Subventricular zone
UR - http://www.scopus.com/inward/record.url?scp=72749091905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72749091905&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2009.11.077
DO - 10.1016/j.neulet.2009.11.077
M3 - Article
C2 - 19962428
AN - SCOPUS:72749091905
VL - 469
SP - 214
EP - 218
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -