A multiparametric study on the prognostic value of epidermal growth factor receptor in operable breast carcinoma

Giampietro Gasparini, Patrizia Boracchi, Pierantonio Bevilacqua, Maura Mezzetti, Franco Pozza, Noel Weidner

Research output: Contribution to journalArticlepeer-review

Abstract

Epidermal growth factor receptor (EGFR) is a potentially useful new biological prognostic and predictive indicator in human breast cancer. Additional research on EGFR is warranted to enhance our information on: i) the method of choice for its detection and quality control issues; ii) its association with novel pathobiological markers of prognosis; iii) its prognostic value in multivariate analysis; and iv) its capability to predict response to hormone therapy and, in the future, to biological treatments using antibodies against the specific receptor or its ligands. In the present study we update previous data on EGFR status, determined immunocytochemically, by prolonging the period of observation up to 5 years and by including, in the multivariate analysis, several new biological indicators. The main results obtained are: i) EGFR is weakly associated with Ki-67 score (p=0.073) and with p53 expression (p=0.06); ii) EGFR is a significant indicator for recurrence (p

Original languageEnglish
Pages (from-to)59-71
Number of pages13
JournalBreast Cancer Research and Treatment
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 1994

Keywords

  • breast cancer
  • epidermal growth factor receptor
  • immunocytochemistry
  • prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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