TY - JOUR
T1 - A multiparametric study on the prognostic value of epidermal growth factor receptor in operable breast carcinoma
AU - Gasparini, Giampietro
AU - Boracchi, Patrizia
AU - Bevilacqua, Pierantonio
AU - Mezzetti, Maura
AU - Pozza, Franco
AU - Weidner, Noel
PY - 1994/1
Y1 - 1994/1
N2 - Epidermal growth factor receptor (EGFR) is a potentially useful new biological prognostic and predictive indicator in human breast cancer. Additional research on EGFR is warranted to enhance our information on: i) the method of choice for its detection and quality control issues; ii) its association with novel pathobiological markers of prognosis; iii) its prognostic value in multivariate analysis; and iv) its capability to predict response to hormone therapy and, in the future, to biological treatments using antibodies against the specific receptor or its ligands. In the present study we update previous data on EGFR status, determined immunocytochemically, by prolonging the period of observation up to 5 years and by including, in the multivariate analysis, several new biological indicators. The main results obtained are: i) EGFR is weakly associated with Ki-67 score (p=0.073) and with p53 expression (p=0.06); ii) EGFR is a significant indicator for recurrence (p
AB - Epidermal growth factor receptor (EGFR) is a potentially useful new biological prognostic and predictive indicator in human breast cancer. Additional research on EGFR is warranted to enhance our information on: i) the method of choice for its detection and quality control issues; ii) its association with novel pathobiological markers of prognosis; iii) its prognostic value in multivariate analysis; and iv) its capability to predict response to hormone therapy and, in the future, to biological treatments using antibodies against the specific receptor or its ligands. In the present study we update previous data on EGFR status, determined immunocytochemically, by prolonging the period of observation up to 5 years and by including, in the multivariate analysis, several new biological indicators. The main results obtained are: i) EGFR is weakly associated with Ki-67 score (p=0.073) and with p53 expression (p=0.06); ii) EGFR is a significant indicator for recurrence (p
KW - breast cancer
KW - epidermal growth factor receptor
KW - immunocytochemistry
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=0028269324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028269324&partnerID=8YFLogxK
U2 - 10.1007/BF00666182
DO - 10.1007/BF00666182
M3 - Article
C2 - 7912568
AN - SCOPUS:0028269324
VL - 29
SP - 59
EP - 71
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 1
ER -