A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling

Marco Boi, Gregorio Marchiori, Maria Sartori, Francesca Salamanna, Gabriela Graziani, Alessandro Russo, Andrea Visani, Mauro Girolami, Milena Fini, Michele Bianchi

Research output: Contribution to journalArticle

Abstract

It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (ER), contact hardness (HC), hardness (H), and viscosity index (ηQ) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process.

Original languageEnglish
Article number7472513
Pages (from-to)1-8
Number of pages8
JournalAdvances in Materials Science and Engineering
Volume2017
Issue number2017
DOIs
Publication statusPublished - 2017

Fingerprint

Bone
Tissue
Mechanical properties
Hardness
Viscosity
Durapatite
Hydroxyapatite
Indentation
Scaffolds
Elastic moduli

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

Cite this

A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling. / Boi, Marco; Marchiori, Gregorio; Sartori, Maria; Salamanna, Francesca; Graziani, Gabriela; Russo, Alessandro; Visani, Andrea; Girolami, Mauro; Fini, Milena; Bianchi, Michele.

In: Advances in Materials Science and Engineering, Vol. 2017, No. 2017, 7472513, 2017, p. 1-8.

Research output: Contribution to journalArticle

Boi, Marco ; Marchiori, Gregorio ; Sartori, Maria ; Salamanna, Francesca ; Graziani, Gabriela ; Russo, Alessandro ; Visani, Andrea ; Girolami, Mauro ; Fini, Milena ; Bianchi, Michele. / A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling. In: Advances in Materials Science and Engineering. 2017 ; Vol. 2017, No. 2017. pp. 1-8.
@article{6ed2628a95a54123a67638b99c301d86,
title = "A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling",
abstract = "It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (ER), contact hardness (HC), hardness (H), and viscosity index (ηQ) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process.",
author = "Marco Boi and Gregorio Marchiori and Maria Sartori and Francesca Salamanna and Gabriela Graziani and Alessandro Russo and Andrea Visani and Mauro Girolami and Milena Fini and Michele Bianchi",
year = "2017",
doi = "10.1155/2017/7472513",
language = "English",
volume = "2017",
pages = "1--8",
journal = "Advances in Materials Science and Engineering",
issn = "1687-8434",
publisher = "Hindawi Publishing Corporation",
number = "2017",

}

TY - JOUR

T1 - A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling

AU - Boi, Marco

AU - Marchiori, Gregorio

AU - Sartori, Maria

AU - Salamanna, Francesca

AU - Graziani, Gabriela

AU - Russo, Alessandro

AU - Visani, Andrea

AU - Girolami, Mauro

AU - Fini, Milena

AU - Bianchi, Michele

PY - 2017

Y1 - 2017

N2 - It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (ER), contact hardness (HC), hardness (H), and viscosity index (ηQ) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process.

AB - It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (ER), contact hardness (HC), hardness (H), and viscosity index (ηQ) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process.

UR - http://www.scopus.com/inward/record.url?scp=85029810175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029810175&partnerID=8YFLogxK

U2 - 10.1155/2017/7472513

DO - 10.1155/2017/7472513

M3 - Article

AN - SCOPUS:85029810175

VL - 2017

SP - 1

EP - 8

JO - Advances in Materials Science and Engineering

JF - Advances in Materials Science and Engineering

SN - 1687-8434

IS - 2017

M1 - 7472513

ER -