A national field study of quality assessment of CoaguChek point-of-care testing prothrombin time monitors

Piet Meijer, Cornelis Kluft, Leon Poller, Felix J M Van Der Meer, Michelle Keown, Saied Ibrahim, Anton M H P Van Den Besselaar, Armando Tripodi, Jørgen Jespersen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A system for quality assessment (QA) of the CoaguChek (Roche Diagnostics, Mannheim, Germany) point-of-care testing prothrombin time monitor has been developed by the European Concerted Action on Anticoagulation. Hitherto there has not been an adequate rapid method for CoaguChek QA. Sets of 5 certified international normalized ratio (INR) plasma samples were tested on 539 CoaguChek monitors by experienced staff at 9 Netherlands Thrombosis Centers and results compared with certified INR. A 15% or more deviation has been classified as significant deviation. Overall mean and certified INR values were similar, but 20.3% of participants showed a 15% or more deviation from the certified INR on at least 1 of the 5 QA plasma samples. Statistically significant differences in results with different lots of CoaguChek test strips were found. There is need for large scale QA of CoaguChek monitors. The importance of the 5 CoaguChek certified INR QA plasma samples being tested on a single occasion is demonstrated.

Original languageEnglish
Pages (from-to)756-761
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume126
Issue number5
DOIs
Publication statusPublished - Nov 2006

Fingerprint

International Normalized Ratio
Prothrombin Time
Netherlands
Germany
Thrombosis
Point-of-Care Testing

Keywords

  • CoaguChek monitors
  • Prothrombin time
  • Quality assessment
  • Significant deviation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Meijer, P., Kluft, C., Poller, L., Van Der Meer, F. J. M., Keown, M., Ibrahim, S., ... Jespersen, J. (2006). A national field study of quality assessment of CoaguChek point-of-care testing prothrombin time monitors. American Journal of Clinical Pathology, 126(5), 756-761. https://doi.org/10.1309/6Q8DY5J1THA8BQG3

A national field study of quality assessment of CoaguChek point-of-care testing prothrombin time monitors. / Meijer, Piet; Kluft, Cornelis; Poller, Leon; Van Der Meer, Felix J M; Keown, Michelle; Ibrahim, Saied; Van Den Besselaar, Anton M H P; Tripodi, Armando; Jespersen, Jørgen.

In: American Journal of Clinical Pathology, Vol. 126, No. 5, 11.2006, p. 756-761.

Research output: Contribution to journalArticle

Meijer, P, Kluft, C, Poller, L, Van Der Meer, FJM, Keown, M, Ibrahim, S, Van Den Besselaar, AMHP, Tripodi, A & Jespersen, J 2006, 'A national field study of quality assessment of CoaguChek point-of-care testing prothrombin time monitors', American Journal of Clinical Pathology, vol. 126, no. 5, pp. 756-761. https://doi.org/10.1309/6Q8DY5J1THA8BQG3
Meijer, Piet ; Kluft, Cornelis ; Poller, Leon ; Van Der Meer, Felix J M ; Keown, Michelle ; Ibrahim, Saied ; Van Den Besselaar, Anton M H P ; Tripodi, Armando ; Jespersen, Jørgen. / A national field study of quality assessment of CoaguChek point-of-care testing prothrombin time monitors. In: American Journal of Clinical Pathology. 2006 ; Vol. 126, No. 5. pp. 756-761.
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