A national multicenter study on 1072 DCIS patients treated with breast-conserving surgery and whole breast radiotherapy (COBCG-01 study)

Clinical Oncology Breast Cancer Group (COBCG) Investigators

Research output: Contribution to journalArticle

Abstract

Background and purpose: Breast-conserving surgery (BCS) and whole breast radiation (RT) with or without endocrine therapy (ET) represent the standard of care for ductal carcinoma in situ (DCIS). The use of adjuvant treatments after surgery is still controversial in this setting. We performed a retrospective multicenter analysis on a series of DCIS patients treated with BCS and adjuvant RT. Materials and methods: We collected clinical data from nine Italian centers on 1072 women having a diagnosis of DCIS and treated between 1997 and 2012. We reported on the 5- and 10-year local recurrence (LR) rates, overall survival, and breast cancer specific survival (BCSS) employing the Kaplan–Meier method. Results: At a median follow-up of 8.4 years, 67 LR (6.3%) and 47 deaths (4.4%) were observed. LR rates at 5 and 10 years were 3.4% and 7.6%, respectively. BCSS rates at 5 and 10 years were 99.7% and 99.1%, respectively. At univariate regression analysis, postmenopausal state (p = 0.009), estrogen receptor (ER) (p = 0.0001) and progesterone receptor (p = 0.018) positivity and ET (p = 0.006) were inversely correlated with LR. Final surgical margins (FSM) status <1 mm was significantly correlated with higher LR (p = 0.003). At multivariate regression analysis postmenopausal state (p = 0.03), and ER positive (p = 0.045) maintained the significant favorable feature, while FSM <1 mm (p = 0.024) confirmed its negative impact on LR. Conclusions: Our real-life study pointed out the significant favorable prognostic role of postmenopausal state and ER positive status on LR occurrence. FSM <1 mm was significantly correlated to a higher chance to experience LR.

Original languageEnglish
JournalRadiotherapy and Oncology
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Carcinoma, Intraductal, Noninfiltrating
Segmental Mastectomy
Multicenter Studies
Breast
Radiotherapy
Recurrence
Estrogen Receptors
Survival Rate
Regression Analysis
Radiation
Breast Neoplasms
Progesterone Receptors
Standard of Care
Therapeutics
Multivariate Analysis
Survival

Keywords

  • Breast cancer
  • Ductal carcinoma in situ
  • Multicenter study
  • Prognostic factors
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

A national multicenter study on 1072 DCIS patients treated with breast-conserving surgery and whole breast radiotherapy (COBCG-01 study). / Clinical Oncology Breast Cancer Group (COBCG) Investigators.

In: Radiotherapy and Oncology, 01.01.2018.

Research output: Contribution to journalArticle

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title = "A national multicenter study on 1072 DCIS patients treated with breast-conserving surgery and whole breast radiotherapy (COBCG-01 study)",
abstract = "Background and purpose: Breast-conserving surgery (BCS) and whole breast radiation (RT) with or without endocrine therapy (ET) represent the standard of care for ductal carcinoma in situ (DCIS). The use of adjuvant treatments after surgery is still controversial in this setting. We performed a retrospective multicenter analysis on a series of DCIS patients treated with BCS and adjuvant RT. Materials and methods: We collected clinical data from nine Italian centers on 1072 women having a diagnosis of DCIS and treated between 1997 and 2012. We reported on the 5- and 10-year local recurrence (LR) rates, overall survival, and breast cancer specific survival (BCSS) employing the Kaplan–Meier method. Results: At a median follow-up of 8.4 years, 67 LR (6.3{\%}) and 47 deaths (4.4{\%}) were observed. LR rates at 5 and 10 years were 3.4{\%} and 7.6{\%}, respectively. BCSS rates at 5 and 10 years were 99.7{\%} and 99.1{\%}, respectively. At univariate regression analysis, postmenopausal state (p = 0.009), estrogen receptor (ER) (p = 0.0001) and progesterone receptor (p = 0.018) positivity and ET (p = 0.006) were inversely correlated with LR. Final surgical margins (FSM) status <1 mm was significantly correlated with higher LR (p = 0.003). At multivariate regression analysis postmenopausal state (p = 0.03), and ER positive (p = 0.045) maintained the significant favorable feature, while FSM <1 mm (p = 0.024) confirmed its negative impact on LR. Conclusions: Our real-life study pointed out the significant favorable prognostic role of postmenopausal state and ER positive status on LR occurrence. FSM <1 mm was significantly correlated to a higher chance to experience LR.",
keywords = "Breast cancer, Ductal carcinoma in situ, Multicenter study, Prognostic factors, Radiotherapy",
author = "{Clinical Oncology Breast Cancer Group (COBCG) Investigators} and Icro Meattini and Nadia Pasinetti and Bruno Meduri and {De Rose}, Fiorenza and {De Santis}, {Maria Carmen} and Pierfrancesco Franco and Valentina Lancellotta and Francesca Rossi and Calogero Saieva and Isacco Desideri and {Delli Paoli}, Camilla and Elisa D'Angelo and Luca Triggiani and Paolo Bastiani and Filippo Alongi and Laura Lozza and Cynthia Aristei and Umberto Ricardi and Marta Scorsetti and Lorenzo Livi",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.radonc.2018.07.015",
language = "English",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
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TY - JOUR

T1 - A national multicenter study on 1072 DCIS patients treated with breast-conserving surgery and whole breast radiotherapy (COBCG-01 study)

AU - Clinical Oncology Breast Cancer Group (COBCG) Investigators

AU - Meattini, Icro

AU - Pasinetti, Nadia

AU - Meduri, Bruno

AU - De Rose, Fiorenza

AU - De Santis, Maria Carmen

AU - Franco, Pierfrancesco

AU - Lancellotta, Valentina

AU - Rossi, Francesca

AU - Saieva, Calogero

AU - Desideri, Isacco

AU - Delli Paoli, Camilla

AU - D'Angelo, Elisa

AU - Triggiani, Luca

AU - Bastiani, Paolo

AU - Alongi, Filippo

AU - Lozza, Laura

AU - Aristei, Cynthia

AU - Ricardi, Umberto

AU - Scorsetti, Marta

AU - Livi, Lorenzo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and purpose: Breast-conserving surgery (BCS) and whole breast radiation (RT) with or without endocrine therapy (ET) represent the standard of care for ductal carcinoma in situ (DCIS). The use of adjuvant treatments after surgery is still controversial in this setting. We performed a retrospective multicenter analysis on a series of DCIS patients treated with BCS and adjuvant RT. Materials and methods: We collected clinical data from nine Italian centers on 1072 women having a diagnosis of DCIS and treated between 1997 and 2012. We reported on the 5- and 10-year local recurrence (LR) rates, overall survival, and breast cancer specific survival (BCSS) employing the Kaplan–Meier method. Results: At a median follow-up of 8.4 years, 67 LR (6.3%) and 47 deaths (4.4%) were observed. LR rates at 5 and 10 years were 3.4% and 7.6%, respectively. BCSS rates at 5 and 10 years were 99.7% and 99.1%, respectively. At univariate regression analysis, postmenopausal state (p = 0.009), estrogen receptor (ER) (p = 0.0001) and progesterone receptor (p = 0.018) positivity and ET (p = 0.006) were inversely correlated with LR. Final surgical margins (FSM) status <1 mm was significantly correlated with higher LR (p = 0.003). At multivariate regression analysis postmenopausal state (p = 0.03), and ER positive (p = 0.045) maintained the significant favorable feature, while FSM <1 mm (p = 0.024) confirmed its negative impact on LR. Conclusions: Our real-life study pointed out the significant favorable prognostic role of postmenopausal state and ER positive status on LR occurrence. FSM <1 mm was significantly correlated to a higher chance to experience LR.

AB - Background and purpose: Breast-conserving surgery (BCS) and whole breast radiation (RT) with or without endocrine therapy (ET) represent the standard of care for ductal carcinoma in situ (DCIS). The use of adjuvant treatments after surgery is still controversial in this setting. We performed a retrospective multicenter analysis on a series of DCIS patients treated with BCS and adjuvant RT. Materials and methods: We collected clinical data from nine Italian centers on 1072 women having a diagnosis of DCIS and treated between 1997 and 2012. We reported on the 5- and 10-year local recurrence (LR) rates, overall survival, and breast cancer specific survival (BCSS) employing the Kaplan–Meier method. Results: At a median follow-up of 8.4 years, 67 LR (6.3%) and 47 deaths (4.4%) were observed. LR rates at 5 and 10 years were 3.4% and 7.6%, respectively. BCSS rates at 5 and 10 years were 99.7% and 99.1%, respectively. At univariate regression analysis, postmenopausal state (p = 0.009), estrogen receptor (ER) (p = 0.0001) and progesterone receptor (p = 0.018) positivity and ET (p = 0.006) were inversely correlated with LR. Final surgical margins (FSM) status <1 mm was significantly correlated with higher LR (p = 0.003). At multivariate regression analysis postmenopausal state (p = 0.03), and ER positive (p = 0.045) maintained the significant favorable feature, while FSM <1 mm (p = 0.024) confirmed its negative impact on LR. Conclusions: Our real-life study pointed out the significant favorable prognostic role of postmenopausal state and ER positive status on LR occurrence. FSM <1 mm was significantly correlated to a higher chance to experience LR.

KW - Breast cancer

KW - Ductal carcinoma in situ

KW - Multicenter study

KW - Prognostic factors

KW - Radiotherapy

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U2 - 10.1016/j.radonc.2018.07.015

DO - 10.1016/j.radonc.2018.07.015

M3 - Article

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JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

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