A network analysis based approach to characterizing periodic sharp wave complexes in electroencephalograms of patients with sporadic CJD

Paolo LoLo Giudice, Domenico Ursino, Nadia Mammone, Francesco Carlo Morabito, Umberto Aguglia, Vittoria Cianci, Edoardo Ferlazzo, Sara Gasparini

Research output: Contribution to journalArticle

Abstract

Creutzfeldt-Jacob disease (CJD) is a rapidly progressive, uniformly fatal transmissible spongiform encephalopathy. Sporadic CJD (sCJD) is the most common form of CJD. Electroencephalography (EEG) is one of the main methods to perform clinical diagnosis of CJD, mainly because of periodic sharp wave complexes (PSWCs). In this paper, we propose a network analysis based approach to characterizing PSWCs in EEGs of patients with sCJD. Our approach associates a network with each EEG at disposal and defines a new numerical coefficient and some network motifs, which characterize the presence of PSWCs in an EEG tracing. The new coefficient, called connection coefficient, and the detected network motifs are capable of characterizing the EEG tracing segments with PSWCs. Furthermore, network motifs are able to detect what are the most active and/or connected brain areas in the tracing segments with PSWCs. The results obtained show that, analogously to what happens for other neurological diseases, network analysis can be successfully exploited to investigate sCJD.

LanguageEnglish
Pages19-29
Number of pages11
JournalInternational Journal of Medical Informatics
Volume121
DOIs
Publication statusPublished - Jan 2019

Cite this

A network analysis based approach to characterizing periodic sharp wave complexes in electroencephalograms of patients with sporadic CJD. / LoLo Giudice, Paolo; Ursino, Domenico; Mammone, Nadia; Morabito, Francesco Carlo; Aguglia, Umberto; Cianci, Vittoria; Ferlazzo, Edoardo; Gasparini, Sara.

In: International Journal of Medical Informatics, Vol. 121, 01.2019, p. 19-29.

Research output: Contribution to journalArticle

LoLo Giudice, Paolo ; Ursino, Domenico ; Mammone, Nadia ; Morabito, Francesco Carlo ; Aguglia, Umberto ; Cianci, Vittoria ; Ferlazzo, Edoardo ; Gasparini, Sara. / A network analysis based approach to characterizing periodic sharp wave complexes in electroencephalograms of patients with sporadic CJD. In: International Journal of Medical Informatics. 2019 ; Vol. 121. pp. 19-29.
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abstract = "Creutzfeldt-Jacob disease (CJD) is a rapidly progressive, uniformly fatal transmissible spongiform encephalopathy. Sporadic CJD (sCJD) is the most common form of CJD. Electroencephalography (EEG) is one of the main methods to perform clinical diagnosis of CJD, mainly because of periodic sharp wave complexes (PSWCs). In this paper, we propose a network analysis based approach to characterizing PSWCs in EEGs of patients with sCJD. Our approach associates a network with each EEG at disposal and defines a new numerical coefficient and some network motifs, which characterize the presence of PSWCs in an EEG tracing. The new coefficient, called connection coefficient, and the detected network motifs are capable of characterizing the EEG tracing segments with PSWCs. Furthermore, network motifs are able to detect what are the most active and/or connected brain areas in the tracing segments with PSWCs. The results obtained show that, analogously to what happens for other neurological diseases, network analysis can be successfully exploited to investigate sCJD.",
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AU - LoLo Giudice, Paolo

AU - Ursino, Domenico

AU - Mammone, Nadia

AU - Morabito, Francesco Carlo

AU - Aguglia, Umberto

AU - Cianci, Vittoria

AU - Ferlazzo, Edoardo

AU - Gasparini, Sara

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2019/1

Y1 - 2019/1

N2 - Creutzfeldt-Jacob disease (CJD) is a rapidly progressive, uniformly fatal transmissible spongiform encephalopathy. Sporadic CJD (sCJD) is the most common form of CJD. Electroencephalography (EEG) is one of the main methods to perform clinical diagnosis of CJD, mainly because of periodic sharp wave complexes (PSWCs). In this paper, we propose a network analysis based approach to characterizing PSWCs in EEGs of patients with sCJD. Our approach associates a network with each EEG at disposal and defines a new numerical coefficient and some network motifs, which characterize the presence of PSWCs in an EEG tracing. The new coefficient, called connection coefficient, and the detected network motifs are capable of characterizing the EEG tracing segments with PSWCs. Furthermore, network motifs are able to detect what are the most active and/or connected brain areas in the tracing segments with PSWCs. The results obtained show that, analogously to what happens for other neurological diseases, network analysis can be successfully exploited to investigate sCJD.

AB - Creutzfeldt-Jacob disease (CJD) is a rapidly progressive, uniformly fatal transmissible spongiform encephalopathy. Sporadic CJD (sCJD) is the most common form of CJD. Electroencephalography (EEG) is one of the main methods to perform clinical diagnosis of CJD, mainly because of periodic sharp wave complexes (PSWCs). In this paper, we propose a network analysis based approach to characterizing PSWCs in EEGs of patients with sCJD. Our approach associates a network with each EEG at disposal and defines a new numerical coefficient and some network motifs, which characterize the presence of PSWCs in an EEG tracing. The new coefficient, called connection coefficient, and the detected network motifs are capable of characterizing the EEG tracing segments with PSWCs. Furthermore, network motifs are able to detect what are the most active and/or connected brain areas in the tracing segments with PSWCs. The results obtained show that, analogously to what happens for other neurological diseases, network analysis can be successfully exploited to investigate sCJD.

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