A neuropsychological study of patients with temporal lobe epilepsy and chronic interictal psychosis

Dominique Flügel, Annette O'Toole, Pamela J. Thompson, Matthias J. Koepp, Mara Cercignani, Mark R. Symms, Jacqueline Foong

Research output: Contribution to journalArticle


Purpose: To characterize the pattern of cognitive deficits in patients with temporal lobe epilepsy (TLE) and interictal (schizophrenia-like) psychosis and to examine the relationship between neuropsychological deficits and Magnetization transfer imaging. Methods: Twenty patients with TLE and interictal psychosis were compared to 20 non-psychotic TLE patients. Patients were matched with respect to premorbid IQ, age and conventional MRI findings. A battery of neuropsychological tests was administered. The neuropsychological tests which showed significant group differences were used for correlational analysis with magnetization transfer ratio (MTR) which provides a quantitative measure of macromolecular structural integrity. Results: Patients with interictal psychosis were significantly more impaired on executive and semantic memory tasks than the non-psychotic TLE group. Vocabulary test scores correlated significantly with MTR reduction in the left fusiform gyrus in the psychotic but not the non-psychotic group. Discussion: In this study, patients with TLE and interictal psychosis were more cognitively impaired than non-psychotic TLE patients. Our findings suggest that the cognitive deterioration in these patients may occur as the illness progresses and the causes for this are probably multifactorial. Our study also provides further evidence that MTR may be useful in investigating structural correlates of cognitive impairment.

Original languageEnglish
Pages (from-to)117-128
Number of pages12
JournalEpilepsy Research
Issue number2-3
Publication statusPublished - Oct 2006



  • Interictal psychosis
  • Magnetization transfer imaging
  • Neuropsychological deficits
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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