A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus

Palmarisa Franchetti, Ghassan Abu Sheikha, Loredana Cappellacci, Stefano Marchetti, Mario Grifantini, Emanuela Balestra, Carlo Federico Perno, Umberto Benatti, Giorgio Brandi, Luigia Rossi, Mauro Magnani

Research output: Contribution to journalArticle

Abstract

The most common therapies against human herpes virus (HSV-1) and human immunodeficiency virus (HIV-1) infectivity are based on the administration of nucleoside analogues. Acyclovir (ACV) is the drug of choice against HSV-1 infection, while the acyclic nucleoside phosphonate analogue PMPA has shown marked anti-HIV activity in a phase I and II clinical studies. As monocyte- derived macrophages are assumed to be important as reservoirs of both HSV-1 and HIV-1 infection, new approaches able to inhibit replication of both viruses in macrophages should be welcome. ACVpPMPA, a new heterodinucleotide consisting of both an antiherpetic and an antiretroviral drug bound by a phosphate bridge, was synthesized and encapsulated into autologous erythrocytes modified to increase their phagocytosis by human macrophages. ACVpPMPA-loaded erythrocytes provided an effective in vitro protection against both HSV-1 and HIV-1 replication in human macrophages. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)149-158
Number of pages10
JournalAntiviral Research
Volume47
Issue number3
DOIs
Publication statusPublished - Sep 2000

Keywords

  • (R)PMPA
  • Acyclovir (ACV)
  • Anti-HIV activity
  • Anti-HSV activity
  • Human macrophages

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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    Franchetti, P., Abu Sheikha, G., Cappellacci, L., Marchetti, S., Grifantini, M., Balestra, E., Perno, C. F., Benatti, U., Brandi, G., Rossi, L., & Magnani, M. (2000). A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus. Antiviral Research, 47(3), 149-158. https://doi.org/10.1016/S0166-3542(00)00101-7