A new approach for seasonal pattern: is it related to bipolarity dimension? Findings from an Italian multicenter study

Andrea Aguglia, Alessandro Cuomo, Andrea Amerio, Simone Bolognesi, Gabriele Di Salvo, Laura Fusar-Poli, Arianna Goracci, Teresa Surace, Gianluca Serafini, Eugenio Aguglia, Mario Amore, Andrea Fagiolini, Giuseppe Maina

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aims of this study were to assess the impact of seasonal pattern on several clinical dimensions in inpatients with a current major depressive episode and to evaluate clinical differences between unipolar and bipolar depression according to seasonal pattern. Methods: Study participants were 300 patients affected by major depressive disorder (MDD) or bipolar disorder (BD) currently experiencing a major depressive episode (MDE) and were recruited at three University Medical Centres in Italy. All study subjects completed several evaluation scales for depressive and hypomanic symptoms, quality of life and functioning, impulsiveness, and seasonal pattern. Results: Several differences between BD with and without seasonal pattern, MDD with and without seasonal pattern but in particular between BD and MDD with seasonal pattern were found. Patients with MDE with seasonal pattern had more frequently received a longitudinal diagnosis of BD. Conclusions: A large number of patients with BD and seasonal pattern, but also a considerable number of patients with MDD and seasonal pattern, endorsed manic items during a current MDE. Seasonal pattern should be associated with a concept of bipolarity in mood disorders and not only related to bipolar disorder. A correct identification of seasonal patterns may lead to the implementation of personalised pharmacological treatment approaches.KEY POINTS High prevalence of mixed features in mood disorders with seasonal pattern, supporting the need for a dimensional approach to major depressive disorder and bipolar disorder. Significant percentage of patients with a primary diagnosis of major depressive disorder had seasonal pattern. Significant percentage of patients with a primary diagnosis of major depressive disorder reported (hypo)manic symptomatology.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalInternational Journal of Psychiatry in Clinical Practice
Volume25
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • bipolar disorder
  • Depressive disorder
  • seasonal pattern
  • seasonality

ASJC Scopus subject areas

  • Psychiatry and Mental health

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