A new approach for the analysis of mass spectrometry data for biomarker discovery.

N. Barbarini, P. Magni, R. Bellazzi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the last few years a growing interest has been devoted to disease diagnosis based on proteomic profiles of body fluids generated by mass spectrometry. In this work, we will present a new approach for their analysis for biomarker discovery. In particular, we will describe a new strategy for the analysis of SELDI/MALDI-TOF serum data based on the following three steps: i) data-preprocessing, ii) feature (mass/charge ratio, m/z) reduction and selection, iii) association of the selected features to a list of compatible known proteins. The method is applied to an ovarian cancer dataset.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
Publication statusPublished - 2006

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Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Body Fluids
Proteomics
Ovarian Neoplasms
Mass Spectrometry
Biomarkers
Serum
Proteins
Datasets

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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