A new approach in the first-line treatment of bacterial and mycotic vulvovaginitis with topical lipohydroperoxides and glycyrrhetic acid: A comparative study

G. Mainini, M. Rotondi, C. Scaffa

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose of investigations: The aim of this randomized controlled trial was to evaluate efficacy and tolerability of a new association of lipohydroperoxides and glycyrrhetic acid on topical treatment of bacterial and mycotic vulvovaginitis. Methods: One hundred consecutive patients with bacterial or mycotic vulvovaginitis were randomly assigned to a study group treated with vaginal lipohy-droperoxides and a derivative of glycyrrhetic acid for three days (n = 50), and a control group using vaginal antibacterial metronidazole (500 mg) or antimycotic econazole (150 mg) for six days (n = 50). Results: A clinical and microbiological response was achieved in 80.4% and 88.9% in investigational and control group, respectively (p > 0.05). Compared to traditional antimicrobial drugs, the effect appears to be faster and safer, even if not significantly. The 6-month recurrence rate was 7.7% and 5.6% in the investigational and control group, respectively. Conclusion: Topical medication based on lipohydroperoxides and glycyrrhetic acid showed a clinical and microbiological efficacy in the first-line treatment of bacterial and mycotic vulvovaginitis, comparable to conventional drugs.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalClinical and Experimental Obstetrics and Gynecology
Volume38
Issue number3
Publication statusPublished - 2011

Keywords

  • Glycyrrhetic acid
  • Lipohydroperoxides
  • Vulvovaginitis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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