A new approach to detect early lung functional impairment in very light smokers

Maurizio Rizzi, Paolo Tarsia, Tiziana La Spina, Andrea Cristiano, Francesca Frassanito, Claudio Macaluso, Andrea Airoldi, Silvia Vanni, Delfino Legnani

Research output: Contribution to journalArticlepeer-review


Purpose The aim of our study is to investigate if lung carbon monoxide diffusing capacity (DLCO) measured during effort is able to detect early respiratory functional impairment. Methods We enrolled 25 very light smokers and 20 healthy non smokers. Subjects underwent plethysmography, DLCO (single breath technique) and calculated effective pulmonary blood flow (Qc) by rebreathing method. During exercise by cycle ergometer (duration 10 ± 2 min; recovery 11 ± 3 min) DLCO and Qc were calculated at 25% and 50% of theoretical maximum workload. Results At baseline lung function and Qc did not differ between groups. DLCO and DLCO/Qc measured during exercise were significantly greater in non smokers (p 

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalRespiratory Physiology and Neurobiology
Publication statusPublished - Sep 1 2016


  • Cardiac output
  • COPD
  • DLCO
  • Smoke
  • Workload

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)


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