A new approach to scaffold fixation by magnetic forces: Application to large osteochondral defects

Alessandro Russo, Tatiana Shelyakova, Daniela Casino, Nicola Lopomo, Alessandro Strazzari, Alessandro Ortolani, Andrea Visani, Valentin Dediu, Maurilio Marcacci

Research output: Contribution to journalArticle

Abstract

Scaffold fixation represents one of the most serious challenges in osteochondral defect surgery. Indeed, the fixation should firmly hold the scaffold in the implanted position as well as it should guaranty stable bone/scaffold interface for efficient tissue regeneration. Nonetheless successful results have been achieved for small defect repair, the fixation remains really problematic for large defects, i.e. defects with areas exceeding 2cm2. This paper advances an innovative magnetic fixation approach based on application of magnetic scaffolds. Finite element modeling was exploited to investigate the fixation efficiency. We considered three magnetic configurations: (1) external permanent magnet ring placed around the leg near the joint; (2) four small permanent magnet pins implanted in the bone underlying the scaffold; (3) four similarly implanted stainless steel pins which magnetization was induced by the external magnet. It was found that for most appropriate magnetic materials and optimized magnet-scaffold positioning all the considered configurations provide a sufficient scaffold fixation. In addition to fixation, we analyzed the pressure induced by magnetic forces at the bone/scaffold interface. Such pressure is known to influence significantly the bone regeneration and could be used for magneto-mechanical stimulation.

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalMedical Engineering and Physics
Volume34
Issue number9
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Magnets
Scaffolds
Defects
Bone and Bones
Bone
Pressure
Bone Regeneration
Stainless Steel
Permanent magnets
Regeneration
Leg
Joints
Tissue regeneration
Magnetic materials
Surgery
Magnetization
Repair
Stainless steel

Keywords

  • Bone and cartilage tissue engineering
  • Magnetic scaffold
  • Osteochondral defect
  • Scaffold fixation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics

Cite this

A new approach to scaffold fixation by magnetic forces : Application to large osteochondral defects. / Russo, Alessandro; Shelyakova, Tatiana; Casino, Daniela; Lopomo, Nicola; Strazzari, Alessandro; Ortolani, Alessandro; Visani, Andrea; Dediu, Valentin; Marcacci, Maurilio.

In: Medical Engineering and Physics, Vol. 34, No. 9, 11.2012, p. 1287-1293.

Research output: Contribution to journalArticle

Russo, Alessandro ; Shelyakova, Tatiana ; Casino, Daniela ; Lopomo, Nicola ; Strazzari, Alessandro ; Ortolani, Alessandro ; Visani, Andrea ; Dediu, Valentin ; Marcacci, Maurilio. / A new approach to scaffold fixation by magnetic forces : Application to large osteochondral defects. In: Medical Engineering and Physics. 2012 ; Vol. 34, No. 9. pp. 1287-1293.
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