A new baby in the c-Myc-directed transcriptional machinery: Che-1/AATF

Valentina Folgiero, Cristina Sorino, Franco Locatelli, Maurizio Fanciulli

Research output: Contribution to journalArticlepeer-review

Abstract

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common malignancy in childhood. Despite the high cure-rate, identifying new druggable molecular targets is still of great interest. In a cohort of BCP-ALL pediatric patients, irrespectively of the molecule/karyotype lesions found, we recently observed high expression of c-Myc and Che-1/AATF, which disappears at time of remission. Study of the molecular mechanisms involved in this co-expression revealed that Che-1 expression was crucial for induction of blast-cell proliferation driven by c-Myc. Furthermore, Che-1/AATF silencing in primary BCP-ALL cell lines improves responsiveness to chemotherapy. These data individuate Che-1 as a possible novel target in the treatment of BCP-ALL able to affect c-Myc-driven tumorigenicity.

Original languageEnglish
Pages (from-to)1286-1290
Number of pages5
JournalCell Cycle
Volume17
Issue number11
DOIs
Publication statusPublished - 2018

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