Abstract
A new synthesis of the valuable penem antibiotics FCE 22101 and FCE 22891 which does not require the use of expensive protecting groups is reported. A mixed carbon-silicon protection of two hydroxy groups was used, followed by a selective enzymatic hydrolysis of the resulting 8-O-protected-2-carboxylic ester (18). Lipase from Chromobacterium viscosum and lipoprotein lipase from Pseudomonas sp. gave excellent results in both free or immobilized form.
Original language | English |
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Pages (from-to) | 1225-1229 |
Number of pages | 5 |
Journal | Journal of the Chemical Society. Perkin Transactions 1 |
Issue number | 7 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Chemistry(all)