A new chemoenzymatic approach to the synthesis of penems

Maria Altamura; Pietro Cesti; Franco Francalanci; Marcello Marchi; Stefano Cambiaghi

A new chemoenzymatic approach to the synthesis of penems

Maria Altamura, Pietro Cesti, Franco Francalanci, Marcello Marchi, Stefano Cambiaghi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

A new synthesis of the valuable penem antibiotics FCE 22101 and FCE 22891 which does not require the use of expensive protecting groups is reported. A mixed carbon-silicon protection of two hydroxy groups was used, followed by a selective enzymatic hydrolysis of the resulting 8-O-protected-2-carboxylic ester (18). Lipase from Chromobacterium viscosum and lipoprotein lipase from Pseudomonas sp. gave excellent results in both free or immobilized form.

Original language	English
Pages (from-to)	1225-1229
Number of pages	5
Journal	Journal of the Chemical Society. Perkin Transactions 1
Issue number	7
Publication status	Published - 1989

ASJC Scopus subject areas

Chemistry(all)

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abstract = "A new synthesis of the valuable penem antibiotics FCE 22101 and FCE 22891 which does not require the use of expensive protecting groups is reported. A mixed carbon-silicon protection of two hydroxy groups was used, followed by a selective enzymatic hydrolysis of the resulting 8-O-protected-2-carboxylic ester (18). Lipase from Chromobacterium viscosum and lipoprotein lipase from Pseudomonas sp. gave excellent results in both free or immobilized form.",

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AU - Cesti, Pietro

AU - Francalanci, Franco

AU - Marchi, Marcello

AU - Cambiaghi, Stefano

PY - 1989

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