A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses

G. Marfe, G. Rotta, L. De Martino, M. Tafani, F. Fiorito, C. Di Stefano, M. Polettini, M. Ranalli, M. A. Russo, A. Gambacurta

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aims: In this study, we present an innovative therapy using stem cells that were obtained from the peripheral blood of racehorses affected by uninduced superficial digital flexor tendon (SDFT) injuries. Main methods: Blood-derived stem cells (BDSCs) were generated from the blood samples of three horses in the presence of macrophage colony-stimulating factor (M-CSF). The racehorses received a single autologous BDSC treatment, which resulted in the successful repair of the tendons injuries. Key findings: The results demonstrated that the BDSCs injection into the damaged tendon stimulated the regeneration of normal tissue. Furthermore, a relationship may exist between the speed and the quality of new tissue formation and the welfare and management of the treated animals. Significance: This study demonstrates that stem cell technology offers new tools for tissue repair that in many cases is considered incurable, and provides additional evidence that BDScs injections increase the speed and quality of the regeneration process in different animal tissues.

Original languageEnglish
Pages (from-to)825-830
Number of pages6
JournalLife Sciences
Volume90
Issue number21-22
DOIs
Publication statusPublished - Jun 6 2012

Fingerprint

Tendon Injuries
Tendons
Stem cells
Horses
Blood
Stem Cells
Tissue
Regeneration
Animals
Repair
Investigational Therapies
Injections
Macrophage Colony-Stimulating Factor
Technology

Keywords

  • Blood-derived stem cells treatment
  • CD117
  • CD34
  • Horse tendons injuries
  • SDFT

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Marfe, G., Rotta, G., De Martino, L., Tafani, M., Fiorito, F., Di Stefano, C., ... Gambacurta, A. (2012). A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses. Life Sciences, 90(21-22), 825-830. https://doi.org/10.1016/j.lfs.2012.03.004

A new clinical approach : Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses. / Marfe, G.; Rotta, G.; De Martino, L.; Tafani, M.; Fiorito, F.; Di Stefano, C.; Polettini, M.; Ranalli, M.; Russo, M. A.; Gambacurta, A.

In: Life Sciences, Vol. 90, No. 21-22, 06.06.2012, p. 825-830.

Research output: Contribution to journalArticle

Marfe, G, Rotta, G, De Martino, L, Tafani, M, Fiorito, F, Di Stefano, C, Polettini, M, Ranalli, M, Russo, MA & Gambacurta, A 2012, 'A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses', Life Sciences, vol. 90, no. 21-22, pp. 825-830. https://doi.org/10.1016/j.lfs.2012.03.004
Marfe, G. ; Rotta, G. ; De Martino, L. ; Tafani, M. ; Fiorito, F. ; Di Stefano, C. ; Polettini, M. ; Ranalli, M. ; Russo, M. A. ; Gambacurta, A. / A new clinical approach : Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses. In: Life Sciences. 2012 ; Vol. 90, No. 21-22. pp. 825-830.
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