A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development

Gerald Hahn, Michael A. Skeide, Dante Mantini, Marco Ganzetti, Alain Destexhe, Angela D. Friederici, Gustavo Deco

Research output: Contribution to journalArticle

Abstract

Recently introduced effective connectivity methods allow for the in-vivo investigation of large-scale functional interactions between brain regions. However, dynamic causal modeling, the most widely used technique to date, typically captures only a few predefined regions of interest. In this study, we present an alternative computational approach to infer effective connectivity within the entire connectome and show its performance on a developmental cohort with emerging language capacities. The novel approach provides new opportunities to quantify effective connectivity changes in the human brain.

Original languageEnglish
Article number8479
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Magnetic resonance imaging
Brain

ASJC Scopus subject areas

  • General

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A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development. / Hahn, Gerald; Skeide, Michael A.; Mantini, Dante; Ganzetti, Marco; Destexhe, Alain; Friederici, Angela D.; Deco, Gustavo.

In: Scientific Reports, Vol. 9, No. 1, 8479, 01.12.2019.

Research output: Contribution to journalArticle

Hahn, Gerald ; Skeide, Michael A. ; Mantini, Dante ; Ganzetti, Marco ; Destexhe, Alain ; Friederici, Angela D. ; Deco, Gustavo. / A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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