Abstract
Objectives: To prospectively assess an innovative computer-aided diagnostic technology that quantifies characteristic features of backscattered ultrasound and theoretically allows transvaginal sonography (TVS) to discriminate benign from malignant adnexal masses. Methods: Women (n=264) scheduled for surgical removal of at least one ovary in five centres were included. Preoperative three-dimensional (3D)-TVS was performed and the voxel data were analysed by the new technology. The findings at 3D-TVS, serum CA125 levels and the TVS-based diagnosis were compared with histology. Cancer was deemed present when invasive or borderline cancerous processes were observed histologically. Results: Among 375 removed ovaries, 141 cancers (83 adenocarcinomas, 24 borderline, 16 cases of carcinomatosis, nine of metastases and nine others) and 234 noncancerous ovaries (107 normal, 127 benign tumours) were histologically diagnosed. The new computer-aided technology correctly identified 138/141 malignant lesions and 206/234 non-malignant tissues (98% sensitivity, 88% specificity). There were no false-negative results among the 47 FIGO stage I/II ovarian lesions. Standard TVS and CA125 had sensitivities/specificities of 94%/66% and 89%/75%, respectively. Combining standard TVS and the new technology in parallel significantly improved TVS specificity from 66% to 92% (p
| Original language | English |
|---|---|
| Pages (from-to) | 1822-1830 |
| Number of pages | 9 |
| Journal | European Radiology |
| Volume | 20 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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Keywords
- Ovarian cancer diagnosis
- Ovarian HistoScanning
- Tissue characterisation
- Ultrasound
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
A new computer-aided diagnostic tool for non-invasive characterisation of malignant ovarian masses : Results of a multicentre validation study. / Lucidarme, Olivier; Akakpo, Jean Paul; Granberg, Seth; Sideri, Mario; Levavi, Hanoch; Schneider, Achim; Autier, Philippe; Nir, Dror; Bleiberg, Harry.
In: European Radiology, Vol. 20, No. 8, 08.2010, p. 1822-1830.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new computer-aided diagnostic tool for non-invasive characterisation of malignant ovarian masses
T2 - Results of a multicentre validation study
AU - Lucidarme, Olivier
AU - Akakpo, Jean Paul
AU - Granberg, Seth
AU - Sideri, Mario
AU - Levavi, Hanoch
AU - Schneider, Achim
AU - Autier, Philippe
AU - Nir, Dror
AU - Bleiberg, Harry
PY - 2010/8
Y1 - 2010/8
N2 - Objectives: To prospectively assess an innovative computer-aided diagnostic technology that quantifies characteristic features of backscattered ultrasound and theoretically allows transvaginal sonography (TVS) to discriminate benign from malignant adnexal masses. Methods: Women (n=264) scheduled for surgical removal of at least one ovary in five centres were included. Preoperative three-dimensional (3D)-TVS was performed and the voxel data were analysed by the new technology. The findings at 3D-TVS, serum CA125 levels and the TVS-based diagnosis were compared with histology. Cancer was deemed present when invasive or borderline cancerous processes were observed histologically. Results: Among 375 removed ovaries, 141 cancers (83 adenocarcinomas, 24 borderline, 16 cases of carcinomatosis, nine of metastases and nine others) and 234 noncancerous ovaries (107 normal, 127 benign tumours) were histologically diagnosed. The new computer-aided technology correctly identified 138/141 malignant lesions and 206/234 non-malignant tissues (98% sensitivity, 88% specificity). There were no false-negative results among the 47 FIGO stage I/II ovarian lesions. Standard TVS and CA125 had sensitivities/specificities of 94%/66% and 89%/75%, respectively. Combining standard TVS and the new technology in parallel significantly improved TVS specificity from 66% to 92% (p
AB - Objectives: To prospectively assess an innovative computer-aided diagnostic technology that quantifies characteristic features of backscattered ultrasound and theoretically allows transvaginal sonography (TVS) to discriminate benign from malignant adnexal masses. Methods: Women (n=264) scheduled for surgical removal of at least one ovary in five centres were included. Preoperative three-dimensional (3D)-TVS was performed and the voxel data were analysed by the new technology. The findings at 3D-TVS, serum CA125 levels and the TVS-based diagnosis were compared with histology. Cancer was deemed present when invasive or borderline cancerous processes were observed histologically. Results: Among 375 removed ovaries, 141 cancers (83 adenocarcinomas, 24 borderline, 16 cases of carcinomatosis, nine of metastases and nine others) and 234 noncancerous ovaries (107 normal, 127 benign tumours) were histologically diagnosed. The new computer-aided technology correctly identified 138/141 malignant lesions and 206/234 non-malignant tissues (98% sensitivity, 88% specificity). There were no false-negative results among the 47 FIGO stage I/II ovarian lesions. Standard TVS and CA125 had sensitivities/specificities of 94%/66% and 89%/75%, respectively. Combining standard TVS and the new technology in parallel significantly improved TVS specificity from 66% to 92% (p
KW - Ovarian cancer diagnosis
KW - Ovarian HistoScanning
KW - Tissue characterisation
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=77957939537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957939537&partnerID=8YFLogxK
U2 - 10.1007/s00330-010-1750-6
DO - 10.1007/s00330-010-1750-6
M3 - Article
C2 - 20306081
AN - SCOPUS:77957939537
VL - 20
SP - 1822
EP - 1830
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 8
ER -