TY - JOUR
T1 - A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia
AU - Tapinassi, Cinzia
AU - Gerbino, Elvira
AU - Malazzi, Omar
AU - Micucci, Carla
AU - Gasparini, Patrizia
AU - Najera, Maria J.
AU - Calasanz, Maria J.
AU - Odero, Maria D.
AU - Pelicci, Pier Giuseppe
AU - Belloni, Elena
PY - 2008/9
Y1 - 2008/9
N2 - A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.
AB - A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.
UR - http://www.scopus.com/inward/record.url?scp=49849086850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49849086850&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2008.05.015
DO - 10.1016/j.cancergencyto.2008.05.015
M3 - Article
C2 - 18722879
AN - SCOPUS:49849086850
VL - 185
SP - 102
EP - 105
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -