A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia

Cinzia Tapinassi; Elvira Gerbino; Omar Malazzi; Carla Micucci; Patrizia Gasparini; Maria J. Najera; Maria J. Calasanz; Maria D. Odero; Pier Giuseppe Pelicci; Elena Belloni

doi:10.1016/j.cancergencyto.2008.05.015

A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia

Cinzia Tapinassi, Elvira Gerbino, Omar Malazzi, Carla Micucci, Patrizia Gasparini, Maria J. Najera, Maria J. Calasanz, Maria D. Odero, Pier Giuseppe Pelicci, Elena Belloni

Research output: Contribution to journal › Article › peer-review

Abstract

A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2008.05.015
Publication status	Published - Sep 2008

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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10.1016/j.cancergencyto.2008.05.015

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A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia. / Tapinassi, Cinzia; Gerbino, Elvira; Malazzi, Omar; Micucci, Carla; Gasparini, Patrizia; Najera, Maria J.; Calasanz, Maria J.; Odero, Maria D.; Pelicci, Pier Giuseppe ; Belloni, Elena.

In: Cancer Genetics and Cytogenetics, Vol. 185, No. 2, 09.2008, p. 102-105.

Research output: Contribution to journal › Article › peer-review

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title = "A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia",

abstract = "A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.",

author = "Cinzia Tapinassi and Elvira Gerbino and Omar Malazzi and Carla Micucci and Patrizia Gasparini and Najera, {Maria J.} and Calasanz, {Maria J.} and Odero, {Maria D.} and Pelicci, {Pier Giuseppe} and Elena Belloni",

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AU - Tapinassi, Cinzia

AU - Gerbino, Elvira

AU - Malazzi, Omar

AU - Micucci, Carla

AU - Gasparini, Patrizia

AU - Najera, Maria J.

AU - Calasanz, Maria J.

AU - Odero, Maria D.

AU - Pelicci, Pier Giuseppe

AU - Belloni, Elena

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AB - A new dic(7;12)(p12.21;p12.2) chromosome aberration was identified in an acute myeloid leukemia with FAB-M1 morphology and was cloned. Fluorescence in situ hybridization and genomic quantitative polymerase chain reaction mapping experiments revealed the precise localization of the breakpoints, at 7p12, just 5′ to the GRB10 gene, and 12p11, within a genomic region containing no known genes. As a result, a new dicentric chromosome is created, dic(7;12), with the consequent deletion of 50 Mb at 7p, from the telomere to the GRB10 region, and of 30 Mb at 12p, from the telomere to p11. Several genes are included in the affected areas.

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A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia

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