TY - JOUR
T1 - A new ELISA assay for islet cell surface antibodies determination in type 1 diabetes mellitus of recent onset
AU - Bizzarro, A.
AU - De Bellis, A.
AU - Florio, A.
AU - Gentile, S.
AU - Amoresano Paglionico, V.
AU - Cacciatore, F.
AU - Iacono, G.
PY - 1992
Y1 - 1992
N2 - Sera from 46 newly diagnosed type 1 diabetic patients and from 100 normal controls were screened for ICA Cf ICA (standard immunofluorescence test) and for ICSA (ELISA assay) detection. Among 46 patients, 33 (71.7%) were ICA positive (16 of them also Cf ICA positive) and 21 resulted ICSA positive (45%). No correlation was found between ICSA, ICA and Cf ICA respectively. Therefore the ICSA detection, by a new and sensitive ELISA assay, in addition to ICA immunofluorescence determination, may be of significant diagnostic value in IDDM of recent onset.
AB - Sera from 46 newly diagnosed type 1 diabetic patients and from 100 normal controls were screened for ICA Cf ICA (standard immunofluorescence test) and for ICSA (ELISA assay) detection. Among 46 patients, 33 (71.7%) were ICA positive (16 of them also Cf ICA positive) and 21 resulted ICSA positive (45%). No correlation was found between ICSA, ICA and Cf ICA respectively. Therefore the ICSA detection, by a new and sensitive ELISA assay, in addition to ICA immunofluorescence determination, may be of significant diagnostic value in IDDM of recent onset.
KW - ELISA assay
KW - islet cell surface antibodies (ICSA)
KW - type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0027008257&partnerID=8YFLogxK
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M3 - Article
C2 - 1490676
AN - SCOPUS:0027008257
SP - 119
EP - 120
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 26
ER -