A new ELISA assay for islet cell surface antibodies determination in type 1 diabetes mellitus of recent onset

A. Bizzarro, A. De Bellis, A. Florio, S. Gentile, V. Amoresano Paglionico, F. Cacciatore, G. Iacono

Research output: Contribution to journalArticlepeer-review

Abstract

Sera from 46 newly diagnosed type 1 diabetic patients and from 100 normal controls were screened for ICA Cf ICA (standard immunofluorescence test) and for ICSA (ELISA assay) detection. Among 46 patients, 33 (71.7%) were ICA positive (16 of them also Cf ICA positive) and 21 resulted ICSA positive (45%). No correlation was found between ICSA, ICA and Cf ICA respectively. Therefore the ICSA detection, by a new and sensitive ELISA assay, in addition to ICA immunofluorescence determination, may be of significant diagnostic value in IDDM of recent onset.

Original languageEnglish
Pages (from-to)119-120
Number of pages2
JournalHormone and Metabolic Research, Supplement
Issue number26
Publication statusPublished - 1992

Keywords

  • ELISA assay
  • islet cell surface antibodies (ICSA)
  • type 1 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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