A new "Era" for the α7-nAChR

Patrizia Russo, Alessio Cardinale, Hildegard Shuller

Research output: Contribution to journalArticle

Abstract

The α7-nAChR plays critical roles in numerous organs and cells by regulating highly organ and cell typespecific functions. In this special issue different Authors have contributed to clarify the different roles played by the α7-nAChR. Post-translational processes such as receptor "underactivation" or "overactivation" are associated in the central nervous system with brain disorders including neurodegeneration, while also contributing to the regulation of nonneuronal cells and cancers derived from them. Current advances in the knowledge of α7-nAChR biology encourage the exploitation of this receptor as a therapeutic target for a variety of diseases, including Alzheimer's, disease, Parkinson's disease, cognitive decline, pain and cancer.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalCurrent Drug Targets
Volume13
Issue number5
Publication statusPublished - May 2012

Keywords

  • α7-nAChR
  • Biological activity
  • Future perspectives
  • New drugs
  • Toxins

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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  • Cite this

    Russo, P., Cardinale, A., & Shuller, H. (2012). A new "Era" for the α7-nAChR. Current Drug Targets, 13(5), 721-725.