TY - JOUR
T1 - A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane
T2 - Results From a Prospective Study
AU - Gagno, Sara
AU - D'Andrea, Mario Rosario
AU - Mansutti, Mauro
AU - Zanusso, Chiara
AU - Puglisi, Fabio
AU - Dreussi, Eva
AU - Montico, Marcella
AU - Biason, Paola
AU - Cecchin, Erika
AU - Iacono, Donatella
AU - Russo, Stefania
AU - Cinausero, Marika
AU - Saracchini, Silvana
AU - Gasparini, Giampietro
AU - Sartori, Donata
AU - Bari, Mario
AU - Collovà, Elena
AU - Meo, Rosa
AU - Merkabaoui, Ghassan
AU - Spagnoletti, Ilaria
AU - Pellegrino, Arianna
AU - Gianni, Lorenzo
AU - Sandri, Paolo
AU - Cretella, Elisabetta
AU - Vattemi, Emanuela
AU - Rocca, Andrea
AU - Serra, Patrizia
AU - Fabbri, Maria Agnese
AU - Benedetti, Giovanni
AU - Foghini, Laura
AU - Medici, Michele
AU - Basso, Umberto
AU - Amoroso, Vito
AU - Riccardi, Ferdinando
AU - Baldelli, Anna Maria
AU - Clerico, Mario
AU - Bonura, Salvatore
AU - Saggia, Chiara
AU - Innocenti, Federico
AU - Toffoli, Giuseppe
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Currently there are no reliable biomarkers to predict outcome of exemestane treatment. We designed a prospective study to investigate whether constitutive genetic background might affect response to therapy. In a population of 302 advanced breast cancer patients treated with exemestane we showed that a 5–polymorphism-based genetic score could be used to identify patients with different risks of progression and death.
AB - Currently there are no reliable biomarkers to predict outcome of exemestane treatment. We designed a prospective study to investigate whether constitutive genetic background might affect response to therapy. In a population of 302 advanced breast cancer patients treated with exemestane we showed that a 5–polymorphism-based genetic score could be used to identify patients with different risks of progression and death.
KW - Advanced breast cancer
KW - Aromatase inhibitor
KW - Hormone therapy
KW - Polymorphisms
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85058825217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058825217&partnerID=8YFLogxK
U2 - 10.1016/j.clbc.2018.11.009
DO - 10.1016/j.clbc.2018.11.009
M3 - Article
AN - SCOPUS:85058825217
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
SN - 1526-8209
ER -